Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder.
Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neurop...
| Autores: | , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| Repositorio: | r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| OAI Identifier: | oai:i3pt.fundanetsuite.com:p6877 |
| Acceso en línea: | https://i3pt.portalinvestigacion.com/publicaciones/6877 https://www.scopus.com/inward/record.uri?eid=2-s2.0-105010092306&doi=10.1038%2Fs41531-025-01058-0&partnerID=40&md5=49b0c9cc52a2913e1722824051699607 |
| Access Level: | acceso abierto |
| Palabra clave: | biological marker aged Article Beck Depression Inventory biological functions clinical article clinical feature cognition controlled study cortical thickness (brain) diffusion tensor imaging education female fluid-attenuated inversion recovery imaging grooved pegboard test human Lewy body male mean diffusivity microstructural changes Mini Mental State Examination neuropsychiatric inventory nuclear magnetic resonance imaging Parkinson disease polysomnography questionnaire REM sleep behavior disorder Rey auditory verbal learning test sociodemographics symbol digit modalities test trail making test Unified Parkinson Disease Rating Scale |
| Sumario: | Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neuropsychological performance is also unknown. We assessed cMD and CTh in thirty-six patients with iRBD at high risk of conversion and 29 healthy controls (HC), examining associations with clinical and cognitive measures. Effect sizes were calculated using Cohen's d. Patients with iRBD showed increased cMD in rostral and caudal cortical regions compared to HC (d > 0.5). Cortical thinning was restricted to caudal areas. Higher cMD correlated with longer iRBD duration, later onset, MDS-UPDRS III, apathy, and poorer performance on Grooved Pegboard and Symbol-Digit Modality Tests. These findings suggest that cMD may be more sensitive than CTh and serve as a valuable imaging biomarker for detecting early cortical changes in prodromal LB diseases. |
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