Cortical Macro- and Microstructural Changes in Parkinson's Disease with Probable Rapid Eye Movement Sleep Behavior Disorder

Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in diffe...

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Detalles Bibliográficos
Autores: Pardo, Jèssica|||0000-0003-4665-4213, Montal, Victor|||0000-0002-5714-9282, Campabadal, Anna|||0000-0002-2833-4884, Oltra, Javier|||0000-0002-9268-4504, Uribe, Carme|||0000-0002-1415-687X, Roura, Ignacio|||0000-0001-8877-899X, Bargalló, Núria|||0000-0001-6284-5402, Martí, Maria J.|||0000-0002-9872-7835, Compta, Yaroslau|||0000-0001-6443-0104, Iranzo, Alex|||0000-0002-5618-8271, Fortea, Juan|||0000-0002-1340-638X, Junqué, Carme|||0000-0002-6381-3063, Segura, Bàrbara|||0000-0002-9673-5479
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:305615
Acceso en línea:https://ddd.uab.cat/record/305615
https://dx.doi.org/urn:doi:10.1002/mds.29761
Access Level:acceso abierto
Palabra clave:Parkinson's disease
Cortical mean diffusivity
Cortical thickness
Magnetic resonance imaging
Rapid eye movement sleep behavior disorder
Descripción
Sumario:Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD-pRBD yet. The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD-pRBD and its relationship with cortical thickness (CTh). Twenty-two PD-pRBD, 31 PD without probable RBD (PD-nonpRBD), and 28 healthy controls (HC) were assessed using 3D T1-weighted and diffusion-weighted magnetic resonance imaging on a 3-T scanner and neuropsychological testing. Measures of cortical brain changes were obtained through cMD and CTh. Two-class group comparisons of a general linear model were performed (P < 0.05). Cohen's d effect size for both approaches was computed. PD-pRBD patients showed higher cMD than PD-nonpRBD patients in the left superior temporal, superior frontal, and precentral gyri, precuneus cortex, as well as in the right middle frontal and postcentral gyri and paracentral lobule (d.

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