Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from th...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad Pública de Navarra |
| Repositorio: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/43953 |
| Acceso en línea: | https://hdl.handle.net/2454/43953 |
| Access Level: | acceso abierto |
| Palabra clave: | Cardio-vascular risk factors Predimed-plus Cardio-vascular disease Depression |
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| dc.title.none.fl_str_mv |
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study |
| title |
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study |
| spellingShingle |
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study Martín Peláez, Sandra Cardio-vascular risk factors Predimed-plus Cardio-vascular disease Depression |
| title_short |
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study |
| title_full |
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study |
| title_fullStr |
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study |
| title_full_unstemmed |
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study |
| title_sort |
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study |
| dc.creator.none.fl_str_mv |
Martín Peláez, Sandra Serra-Majem, Lluis Cano Ibáñez, Noemí Martínez González, Miguel Ángel Salas-Salvadó, Jordi Corella, Dolores Lassale, Camille Martínez, José Alfredo Alonso Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López Miranda, José Estruch, Ramón Tinahones, Francisco J. Lapetra, José Fernández-Aranda, Fernando Bueno Cavanillas, Aurora Tur, Josep A. Martín, Vicente Pintó, Xavier Delgado Rodríguez, Miguel Matía-Martín, Pilar Vidal, Josep Vázquez, Clotilde Daimiel, Lidia Ros, Emilio Toledo, Estefanía Nishi, Stephanie K. Sorli, Jose V. Malcampo, Mireia Zulet, María Ángeles Moreno Rodríguez, Anaí Cueto Galán, Raquel Vivancos Aparicio, Diego Colom Fernández, Antoni García-Ríos, Antonio Casas, Rosa Bernal López, M. Rosa Santos Lozano, José Manuel Vázquez, Zenaida Gómez-Martínez, Carlos Ortega Azorín, Carolina Val, José Luis del Abete, Itziar Goikoetxea Bahon, Amaia Pascual, Elena Becerra-Tomás, Nerea Chillarón, Juan J. Sánchez Villegas, María Almudena |
| author |
Martín Peláez, Sandra |
| author_facet |
Martín Peláez, Sandra Serra-Majem, Lluis Cano Ibáñez, Noemí Martínez González, Miguel Ángel Salas-Salvadó, Jordi Corella, Dolores Lassale, Camille Martínez, José Alfredo Alonso Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López Miranda, José Estruch, Ramón Tinahones, Francisco J. Lapetra, José Fernández-Aranda, Fernando Bueno Cavanillas, Aurora Tur, Josep A. Martín, Vicente Pintó, Xavier Delgado Rodríguez, Miguel Matía-Martín, Pilar Vidal, Josep Vázquez, Clotilde Daimiel, Lidia Ros, Emilio Toledo, Estefanía Nishi, Stephanie K. Sorli, Jose V. Malcampo, Mireia Zulet, María Ángeles Moreno Rodríguez, Anaí Cueto Galán, Raquel Vivancos Aparicio, Diego Colom Fernández, Antoni García-Ríos, Antonio Casas, Rosa Bernal López, M. Rosa Santos Lozano, José Manuel Vázquez, Zenaida Gómez-Martínez, Carlos Ortega Azorín, Carolina Val, José Luis del Abete, Itziar Goikoetxea Bahon, Amaia Pascual, Elena Becerra-Tomás, Nerea Chillarón, Juan J. Sánchez Villegas, María Almudena |
| author_role |
author |
| author2 |
Serra-Majem, Lluis Cano Ibáñez, Noemí Martínez González, Miguel Ángel Salas-Salvadó, Jordi Corella, Dolores Lassale, Camille Martínez, José Alfredo Alonso Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López Miranda, José Estruch, Ramón Tinahones, Francisco J. Lapetra, José Fernández-Aranda, Fernando Bueno Cavanillas, Aurora Tur, Josep A. Martín, Vicente Pintó, Xavier Delgado Rodríguez, Miguel Matía-Martín, Pilar Vidal, Josep Vázquez, Clotilde Daimiel, Lidia Ros, Emilio Toledo, Estefanía Nishi, Stephanie K. Sorli, Jose V. Malcampo, Mireia Zulet, María Ángeles Moreno Rodríguez, Anaí Cueto Galán, Raquel Vivancos Aparicio, Diego Colom Fernández, Antoni García-Ríos, Antonio Casas, Rosa Bernal López, M. Rosa Santos Lozano, José Manuel Vázquez, Zenaida Gómez-Martínez, Carlos Ortega Azorín, Carolina Val, José Luis del Abete, Itziar Goikoetxea Bahon, Amaia Pascual, Elena Becerra-Tomás, Nerea Chillarón, Juan J. Sánchez Villegas, María Almudena |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Institute on Innovation and Sustainable Development in Food Chain - ISFOOD |
| dc.subject.none.fl_str_mv |
Cardio-vascular risk factors Predimed-plus Cardio-vascular disease Depression |
| topic |
Cardio-vascular risk factors Predimed-plus Cardio-vascular disease Depression |
| description |
Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2454/43953 |
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https://hdl.handle.net/2454/43953 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
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Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal studyMartín Peláez, SandraSerra-Majem, LluisCano Ibáñez, NoemíMartínez González, Miguel ÁngelSalas-Salvadó, JordiCorella, DoloresLassale, CamilleMartínez, José AlfredoAlonso Gómez, Ángel M.Wärnberg, JuliaVioque, JesúsRomaguera, DoraLópez Miranda, JoséEstruch, RamónTinahones, Francisco J.Lapetra, JoséFernández-Aranda, FernandoBueno Cavanillas, AuroraTur, Josep A.Martín, VicentePintó, XavierDelgado Rodríguez, MiguelMatía-Martín, PilarVidal, JosepVázquez, ClotildeDaimiel, LidiaRos, EmilioToledo, EstefaníaNishi, Stephanie K.Sorli, Jose V.Malcampo, MireiaZulet, María ÁngelesMoreno Rodríguez, AnaíCueto Galán, RaquelVivancos Aparicio, DiegoColom Fernández, AntoniGarcía-Ríos, AntonioCasas, RosaBernal López, M. RosaSantos Lozano, José ManuelVázquez, ZenaidaGómez-Martínez, CarlosOrtega Azorín, CarolinaVal, José Luis delAbete, ItziarGoikoetxea Bahon, AmaiaPascual, ElenaBecerra-Tomás, NereaChillarón, Juan J.Sánchez Villegas, María AlmudenaCardio-vascular risk factorsPredimed-plusCardio-vascular diseaseDepressionBackground Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.The PREDIMED-Plus trial was supported by the European Research Council through a grant to MAM (Advanced Research Grant 2013-2018; 340918). The project was also supported by the official funding agency for biomedical research of the Spanish Government (ISCIII) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects), who awarded grants to JS and JV (PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732 and PI17/00926). The International Nut&Dried Fruit Council-FESNAD also provided funding through a grant to MAM (201302), and Recercaixa also awarded a grant to JS (2013ACUP00194). The Department of Health, Generalitat de Cataluña by the calls 'Acció instrumental de programes de recerca orientats en lámbit de la recercaila innovació en salut' and 'Pla estrategic de recerca i innovació en salut (PERIS),' also awarded a grant to FF (SLT006/17/00246). This research was also partially funded by: Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); Generalitat Valenciana (PROMETEO/2017/017); SEMERGEN, CIBEROBN, FEDER and ISCIII (CB06/03); EU-H2020 Grants (Eat2beNICE/h2020-sfs-2016-2, ref.728018; PRIME/h2020-SC1-BHC-2018-2020, ref: 847879).PLOSInstitute on Innovation and Sustainable Development in Food Chain - ISFOOD2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/43953reponame:Academica-e. 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This is an open access article distributed under the terms of the Creative Commons Attribution Licensehttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/439532026-06-17T12:41:47Z |
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