Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from th...

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Autores: Martín Peláez, Sandra, Serra-Majem, Lluis, Cano Ibáñez, Noemí, Martínez González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Lassale, Camille, Martínez, José Alfredo, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Fernández-Aranda, Fernando, Bueno Cavanillas, Aurora, Tur, Josep A., Martín, Vicente, Pintó, Xavier, Delgado Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Nishi, Stephanie K., Sorli, Jose V., Malcampo, Mireia, Zulet, María Ángeles, Moreno Rodríguez, Anaí, Cueto Galán, Raquel, Vivancos Aparicio, Diego, Colom Fernández, Antoni, García-Ríos, Antonio, Casas, Rosa, Bernal López, M. Rosa, Santos Lozano, José Manuel, Vázquez, Zenaida, Gómez-Martínez, Carlos, Ortega Azorín, Carolina, Val, José Luis del, Abete, Itziar, Goikoetxea Bahon, Amaia, Pascual, Elena, Becerra-Tomás, Nerea, Chillarón, Juan J., Sánchez Villegas, María Almudena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/43953
Acceso en línea:https://hdl.handle.net/2454/43953
Access Level:acceso abierto
Palabra clave:Cardio-vascular risk factors
Predimed-plus
Cardio-vascular disease
Depression
Descripción
Sumario:Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.

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