Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

Background: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from t...

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Authors: Martín-Peláez, S. (Sandra)|||/items/514e6880-d0b1-469f-84c2-0ce6a706e0f5, Serra-Majem, L. (Lluís)|||/items/e6a3f618-abe3-45ec-b2db-0c8cb55501ea, Cano-Ibañez, N. (Naomi)|||/items/5af1b303-5617-4f66-ace4-8bc134271ca1, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6, Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41, Lassale, C. (Camille)|||/items/e84cbc2f-fd37-412d-b6b5-3d91c33489bd, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131, Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d, Wärnberg, J. (Julia)|||/items/7ec96886-31ab-4a1d-8eb6-8cac5dabcc68, Vioque, J. (Jesús)|||/items/5ea91c65-f01c-445e-b1e3-ed2c3ba305ff, Romaguera, D. (Dora)|||/items/54bd463f-ee9f-4c7a-b33e-78633766680a, López-Miranda, J. (José)|||/items/4f655f19-45e0-474d-84e8-c4146e2f80be, Estruch, R. (Ramón)|||/items/3e95ff5c-8b32-474d-a8d4-7b1425d89265, Tinahones, F.J. (Francisco J.)|||/items/3c469348-deec-4066-bd93-383e05813c10, Lapetra, J. (José)|||/items/c14c3d23-c16a-4a2c-9a96-e1088196339d, Bueno-Cavanillas, A. (Aurora)|||/items/52c3c11e-94cf-42e6-9733-4b94d41bbe82, Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e, Martin, V. (Vicente)|||/items/f5e6eab9-a1d6-488b-adc9-10bdb0e4a2a5, Pinto, X. (Xavier)|||/items/4c705373-b9ef-443a-be57-4ae3aea0fe1b, Delgado-Rodriguez, M. (Miguel)|||/items/ca205594-7841-487f-81dd-077f45dcee82, Matia, P. (Pilar)|||/items/b7f93927-14ce-43b0-bd20-24d9ad2cb2ab, Vidal, J. (Josep)|||/items/d6726d60-5635-4d9b-bc17-38373121f507, Vázquez, C. (Clotilde)|||/items/8d0a4262-228e-46c7-a251-d8944ef45ead, Daimiel, L. (Lidia)|||/items/08a75614-1e56-4c06-8dce-3848f7f673dd, Ros, E. (Emili)|||/items/31ec4fa7-b409-4111-9372-ab3a96fb5e4b, Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0, Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239, Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb, Pascual-Roquet-Jalmar, E. (Elena)|||/items/4dda96cc-532f-457f-8e6d-d1773c852d4a, Sanchez-Villegas, A. (Almudena)|||/items/89570c42-5fec-4682-b219-d901781ef99d
Format: article
Publication Date:2022
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/116547
Online Access:https://hdl.handle.net/10171/116547
Access Level:Open access
Keyword:Cardio-vascular disease
Depression
PREDIMED-Plus trial
Description
Summary:Background: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).

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