Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?

Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies ('precision vaccination'). If baseline immune sig...

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Detalles Bibliográficos
Autores: Tsang, John S., Dobaño, Carlota, 1969-, VanDamme, Pierre, Moncunill Piñas, Gemma, Marchant, Arnaud, Othman, Rym Ben, Sadarangani, Manish, Koff, Wayne C., Kollmann, Tobias R.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/162635
Acceso en línea:https://hdl.handle.net/2445/162635
Access Level:acceso abierto
Palabra clave:Vacunació
Immunitat
Vaccination
Immunity
Descripción
Sumario:Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies ('precision vaccination'). If baseline immune signatures are predictive, the underlying mechanism they reflect may also determine vaccination outcome. Thus, baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses. This concept has the potential to transform vaccination strategies and usher in a new approach to improve global health.