Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?

Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies ('precision vaccination'). If baseline immune sig...

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Bibliographic Details
Authors: Tsang, John S., Dobaño, Carlota, 1969-, VanDamme, Pierre, Moncunill Piñas, Gemma, Marchant, Arnaud, Othman, Rym Ben, Sadarangani, Manish, Koff, Wayne C., Kollmann, Tobias R.
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/162635
Online Access:https://hdl.handle.net/2445/162635
Access Level:Open access
Keyword:Vacunació
Immunitat
Vaccination
Immunity
Description
Summary:Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies ('precision vaccination'). If baseline immune signatures are predictive, the underlying mechanism they reflect may also determine vaccination outcome. Thus, baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses. This concept has the potential to transform vaccination strategies and usher in a new approach to improve global health.

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