Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination

With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic protei...

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Detalles Bibliográficos
Autores: Gómez Preciado, Francisco, De Carvalho Ovalles, Rosa Alejandra, Codina, Sergi|||0000-0002-2313-6109, Donadeu, Laura|||0000-0002-5089-5047, Favà, Alexandre|||0000-0003-1664-6001, Martinez Valenzuela, Laura, Sandoval, Diego, Fernández-Cidón, Bárbara|||0000-0001-5547-480X, Bestard Matamoros, Oriol|||0000-0001-9468-7920, Alía Ramos, Pedro|||0000-0001-9662-6283, Gomà-i-Freixanet, Montserrat|||0000-0003-3146-1750, Melilli, Edoardo|||0000-0001-6965-3745, Cruzado, Josep María
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:292206
Acceso en línea:https://ddd.uab.cat/record/292206
https://dx.doi.org/urn:doi:10.3390/jcm11133651
Access Level:acceso abierto
Palabra clave:SARS-CoV-2
Vaccine
COVID-19
Collapsing
Glomerulonephritis
Mrna
Descripción
Sumario:With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also.

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