SARS-CoV-2-Spike Antibody and T-Cell Responses Elicited by a Homologous Third mRNA COVID-19 Dose in Hemodialysis and Kidney Transplant Recipients

The effect of a third vaccine dose (3D) of homologous mRNA vaccine on blood levels of SARS-CoV-2-receptor binding domain (RBD)-total antibodies was assessed in 40 hemodialysis patients (HD) and 21 kidney transplant recipients (KTR) at a median of 46 days after 3D. Anti-RBD antibodies were detected i...

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Detalles Bibliográficos
Autores: Panizo, Nayara, Gimenez, Estela, Albert, Eliseo, Zulaica, Joao, Rodriguez-Moreno, Alicia, Rusu, Luciana, Gimenez-Civera, Elena, Puchades, Maria Jesus, D'Marco, Luis, Gandia-Salmeron, Lorena, Torres, Ignacio, Sancho, Asuncion, Gavela, Eva, Gonzalez-Rico, Miguel, Montomoli, Marco, Perez-Baylach, Carmen Maria, Bonilla, Begona, Solano, Camila, Alvarado, M Fernanda, Torregrosa, Isidro, Gonzales-Candia, Boris, Alcaraz, Maria Jesus, Geller, Ron, Gorriz, Jose Luis, Navarro, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17033
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/17033
Access Level:acceso abierto
Palabra clave:mRNA COVID-19 vaccine
SARS-CoV-2-S antibodies
SARS-CoV-2-S T cells
neutralizing antibodies
hemodialysis
kidney transplantation
Descripción
Sumario:The effect of a third vaccine dose (3D) of homologous mRNA vaccine on blood levels of SARS-CoV-2-receptor binding domain (RBD)-total antibodies was assessed in 40 hemodialysis patients (HD) and 21 kidney transplant recipients (KTR) at a median of 46 days after 3D. Anti-RBD antibodies were detected in 39/40 HD and 19/21 KTR. Overall, 3D boosted anti-RBD antibody levels (median: 58-fold increase). Neutralizing antibodies (NtAb) against the Wuhan-Hu-1, Delta, and Omicron variants were detected in 14, 13, and 11 out of 14 HD patients, and in 5, 5, and 4 out of 8 KTR patients, respectively. The median fold increase in NtAb titers in HD patients was 77, 28, and 5 and 56, 37, and 9 in KTR patients for each respective variant. SARS-CoV-2-S S-IFN-gamma-producing CD8(+) and CD4(+) T-cell responses were detected in the majority of HD (35 and 36/37, respectively) and all KTR (16/16) patients at 3D. Overall, the administration of 3D boosted T-cell levels in both population groups. In conclusion, a homologous mRNA COVID-19 vaccine 3D exerts a booster effect on anti-RBD antibodies, NtAb binding to Wuhan-Hu-1, Delta, and Omicron variants, and SARS-CoV-2-S-IFN-gamma-producing T cells in both HD and KTR patients. The magnitude of the effect was more marked in HD than KTR patients.

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