Collapsing Glomerulonephritis in a Kidney Transplant Recipient after mRNA SARS-CoV-2 Vaccination

With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic protei...

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Detalles Bibliográficos
Autores: Gómez Preciado, Francisco, Carvalho Ovalles, Rosa Alejandra de, Codina, Sergi, Donadeu, Laura, Favà Buch, Alexandre, Martinez Valenzuela, Laura, Sandoval, Diego, Fernández Cidón, Bárbara, Bestard Matamoros, Oriol, Alia Ramos, Pedro, Gomà, Montse, Melilli, Edoardo, Cruzado, Josep Ma.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/187969
Acceso en línea:https://hdl.handle.net/2445/187969
Access Level:acceso abierto
Palabra clave:COVID-19
Vacunació
Trasplantament renal
Glomerulonefritis
Vaccination
Kidney transplantation
Glomerulonephritis
Descripción
Sumario:With the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), studies are describing cases of glomerulonephritis arising after vaccination. We present the first case of a kidney transplant patient who, after mRNA vaccination against SARS-CoV-2, developed nephrotic proteinuria and renal dysfunction, with a biopsy diagnostic of collapsing glomerulonephritis. No other triggers for this glomerulonephritis were identified. Antibodies against the spike protein were negative, but the patient developed a specific T-cell response. The close time between vaccination and the proteinuria suggests a possible determinant role of vaccination. We should be aware of nephropathies appearing after COVID-19 vaccination in kidney transplant recipients also.

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