Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5years old in Spain
Introduction: Up to date the impact of rotavirus (RV) vaccines on seizures has been poorly evaluated, with some studies but not all, showing different degrees of protection.Objectives: To assess the impact of RV vaccines on convulsions-related hospitalizations among children under 5years of age resi...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p2834 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/2834 |
| Access Level: | acceso abierto |
| Palabra clave: | Child hospitalization Impact Rotavirus Seizures Spain vaccines |
| Sumario: | Introduction: Up to date the impact of rotavirus (RV) vaccines on seizures has been poorly evaluated, with some studies but not all, showing different degrees of protection.Objectives: To assess the impact of RV vaccines on convulsions-related hospitalizations among children under 5years of age residing in the Region of Valencia, Spain.Methods: A population-based, ecological study using the hospital discharge record (MBDS), the population-based administrative database (SIP) and the vaccine register (SIV), among Valencia Region's children <5years old, during 2003 - 2015. Impact of vaccination on seizures-related hospitalization rates (780.3* ICD-9-MC code) was estimated by a multivariate Bayesian mixed Poisson regression model.Results: Since RV vaccines licensure in 2007, its coverage rate increased up to around 42%. When the impact of vaccination against seizures was controlled for potential confounders in the multivariate analysis, there was a non-statistically significant protective effect.Conclusions: We could not find any impact of RV vaccine coverage on seizure-related hospitalizations in children <5 years. |
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