Impact of rotavirus vaccination on seizure hospitalizations in children: A systematic review
Background: Previous studies found conflicting results about the effect of rotavirus (RV) vaccination on seizure hospitalizations in children younger than 5 years old. Objectives: To evaluate the evidence of the impact of RV vaccination on the prevention of seizure hospitalizations in children. Meth...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad Católica de Valencia San Vicente Mártir |
| Repositorio: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| Idioma: | inglés |
| OAI Identifier: | oai:riucv.ucv.es:20.500.12466/3740 |
| Acceso en línea: | http://hdl.handle.net/20.500.12466/3740 |
| Access Level: | acceso abierto |
| Palabra clave: | Rotavirus Rotavirus vaccines Seizures Convusions Children 2412.10 Vacunas |
| Sumario: | Background: Previous studies found conflicting results about the effect of rotavirus (RV) vaccination on seizure hospitalizations in children younger than 5 years old. Objectives: To evaluate the evidence of the impact of RV vaccination on the prevention of seizure hospitalizations in children. Methods: A systematic review was conducted in the electronic database MEDLINE of all observational studies in children younger than 5 years old published since 2006. Two reviewers performed title/abstract, full-text review, and data extraction. Results: Thirteen studies met eligibility criteria. Nine studies reported a significant reduction in seizure hospitalizations upon RV vaccine introduction, three studies reported an absence of significant impact, and one study reported a significant rise in seizure hospitalization after the introduction of RV vaccines. Limitations: The great variability between study designs, case definitions and potential biases prevent quantifying the impact of RV vaccination against seizure hospitalizations. Conclusions: RV vaccination might prevent seizure hospitalizations in children; however, robust, and well-designed studies are needed to better determine the strength of this association |
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