Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain
Introduction: Up to date the impact of rotavirus (RV) vaccines on seizures has been poorly evaluated, with some studies but not all, showing different degrees of protection. Objectives: To assess the impact of RV vaccines on convulsions-related hospitalizations among children under 5 years of age re...
| Authors: | , , , |
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| Format: | article |
| Publication Date: | 2018 |
| Country: | España |
| Institution: | Universidad Católica de Valencia San Vicente Mártir |
| Repository: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| Language: | English |
| OAI Identifier: | oai:riucv.ucv.es:20.500.12466/3674 |
| Online Access: | http://hdl.handle.net/20.500.12466/3674 |
| Access Level: | Open access |
| Keyword: | Children Hospitalization Impact Rotavirus Seizures Spain Vaccines 2412.10 Vacunas |
| Summary: | Introduction: Up to date the impact of rotavirus (RV) vaccines on seizures has been poorly evaluated, with some studies but not all, showing different degrees of protection. Objectives: To assess the impact of RV vaccines on convulsions-related hospitalizations among children under 5 years of age residing in the Region of Valencia, Spain. Methods: A population-based, ecological study using the hospital discharge record (MBDS), the populationbased administrative database (SIP) and the vaccine register (SIV), among Valencia Region’s children <5 years old, during 2003 – 2015. Impact of vaccination on seizures-related hospitalization rates (780.3 ICD-9-MC code) was estimated by a multivariate Bayesian mixed Poisson regression model. Results: Since RV vaccines licensure in 2007, its coverage rate increased up to around 42%. When the impact of vaccination against seizures was controlled for potential confounders in the multivariate analysis, there was a non-statistically significant protective effect. Conclusions: We could not find any impact of RV vaccine coverage on seizure-related hospitalizations in children <5 years. |
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