Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity

Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-ar...

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Autores: Miranda Olivos, Romina, Baenas, Isabel, Steward, Trevor, Granero, Roser, Pastor, Antoni, Sánchez, Isabel, Juaneda Seguí, Asier, Pino Gutiérrez, Amparo Del, Fernández Formoso, Jose A., Vilarrasa, Nuria, Guerrero Pérez, Fernando, Virgili, Núria, López Urdiales, Rafael, Jiménez-Murcia, Susana, Torre Fornell, Rafael de la, Soriano Mas, Carles, Fernández Aranda, Fernando
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214744
Acceso en línea:http://hdl.handle.net/2445/214744
Access Level:acceso abierto
Palabra clave:Anorèxia nerviosa
Imatges per ressonància magnètica
Pes corporal
Neurotransmissors
Anorexia nervosa
Magnetic resonance imaging
Body weight
Neurotransmitters
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spelling Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severityMiranda Olivos, RominaBaenas, IsabelSteward, TrevorGranero, RoserPastor, AntoniSánchez, IsabelJuaneda Seguí, AsierPino Gutiérrez, Amparo DelFernández Formoso, Jose A.Vilarrasa, NuriaGuerrero Pérez, FernandoVirgili, NúriaLópez Urdiales, RafaelJiménez-Murcia, SusanaTorre Fornell, Rafael de laSoriano Mas, CarlesFernández Aranda, FernandoAnorèxia nerviosaImatges per ressonància magnèticaPes corporalNeurotransmissorsAnorexia nervosaMagnetic resonance imagingBody weightNeurotransmittersAnorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula; pFWE < 0.001) and the left supplementary motor area (NAcc-SMA; pFWE < 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.Nature Publishing Group2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion8 p.application/pdfhttp://hdl.handle.net/2445/214744http://hdl.handle.net/2445/214744Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1038/s41380-023-02253-2Molecular Psychiatry, 2023, vol. 28, num.11, p. 4793-4800https://doi.org/10.1038/s41380-023-02253-2(c) Miranda-Olivos Romina et al., 2023info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2147442026-05-29T05:05:01Z
dc.title.none.fl_str_mv Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
title Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
spellingShingle Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
Miranda Olivos, Romina
Anorèxia nerviosa
Imatges per ressonància magnètica
Pes corporal
Neurotransmissors
Anorexia nervosa
Magnetic resonance imaging
Body weight
Neurotransmitters
title_short Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
title_full Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
title_fullStr Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
title_full_unstemmed Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
title_sort Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity
dc.creator.none.fl_str_mv Miranda Olivos, Romina
Baenas, Isabel
Steward, Trevor
Granero, Roser
Pastor, Antoni
Sánchez, Isabel
Juaneda Seguí, Asier
Pino Gutiérrez, Amparo Del
Fernández Formoso, Jose A.
Vilarrasa, Nuria
Guerrero Pérez, Fernando
Virgili, Núria
López Urdiales, Rafael
Jiménez-Murcia, Susana
Torre Fornell, Rafael de la
Soriano Mas, Carles
Fernández Aranda, Fernando
author Miranda Olivos, Romina
author_facet Miranda Olivos, Romina
Baenas, Isabel
Steward, Trevor
Granero, Roser
Pastor, Antoni
Sánchez, Isabel
Juaneda Seguí, Asier
Pino Gutiérrez, Amparo Del
Fernández Formoso, Jose A.
Vilarrasa, Nuria
Guerrero Pérez, Fernando
Virgili, Núria
López Urdiales, Rafael
Jiménez-Murcia, Susana
Torre Fornell, Rafael de la
Soriano Mas, Carles
Fernández Aranda, Fernando
author_role author
author2 Baenas, Isabel
Steward, Trevor
Granero, Roser
Pastor, Antoni
Sánchez, Isabel
Juaneda Seguí, Asier
Pino Gutiérrez, Amparo Del
Fernández Formoso, Jose A.
Vilarrasa, Nuria
Guerrero Pérez, Fernando
Virgili, Núria
López Urdiales, Rafael
Jiménez-Murcia, Susana
Torre Fornell, Rafael de la
Soriano Mas, Carles
Fernández Aranda, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anorèxia nerviosa
Imatges per ressonància magnètica
Pes corporal
Neurotransmissors
Anorexia nervosa
Magnetic resonance imaging
Body weight
Neurotransmitters
topic Anorèxia nerviosa
Imatges per ressonància magnètica
Pes corporal
Neurotransmissors
Anorexia nervosa
Magnetic resonance imaging
Body weight
Neurotransmitters
description Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula; pFWE < 0.001) and the left supplementary motor area (NAcc-SMA; pFWE < 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/2445/214744
http://hdl.handle.net/2445/214744
url http://hdl.handle.net/2445/214744
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1038/s41380-023-02253-2
Molecular Psychiatry, 2023, vol. 28, num.11, p. 4793-4800
https://doi.org/10.1038/s41380-023-02253-2
dc.rights.none.fl_str_mv (c) Miranda-Olivos Romina et al., 2023
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Miranda-Olivos Romina et al., 2023
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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