Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity

Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-ar...

Descripción completa

Detalles Bibliográficos
Autores: Miranda-Olivos, Romina|||0000-0003-2360-5830, Baenas Soto, Isabel Maria|||0000-0001-7415-0616, Steward, Trevor|||0000-0003-3116-8175, Granero, Roser|||0000-0001-6308-3198, Pastor, Antoni|||0000-0003-3692-0696, Sánchez Díaz, Isabel María|||0000-0001-5874-8204, Juaneda-Seguí, Asier, Del Pino Gutiérrez, Amparo|||0000-0002-2854-9850, Fernandez Formoso, Jose Antonio|||0000-0001-5310-1655, Vilarrasa, Nuria|||0000-0003-3188-1990, Guerrero-Pérez, Fernando, Virgili, Nuria, López-Urdiales, Rafael|||0000-0002-2355-3041, Jiménez Murcia, Susana|||0000-0002-3596-8033, Torre, Rafael de la|||0000-0002-6765-1866, Soriano-Mas, Carles|||0000-0003-4574-6597, Fernández Aranda, Fernando|||0000-0002-2968-9898
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:291543
Acceso en línea:https://ddd.uab.cat/record/291543
https://dx.doi.org/urn:doi:10.1038/s41380-023-02253-2
Access Level:acceso abierto
Palabra clave:Neuroscience
Psychiatric disorders
Anorexia nervosa
Descripción
Sumario:Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula; p < 0.001) and the left supplementary motor area (NAcc-SMA; p < 0.001) in the AN group compared to HC. Reduced NAcc-insula functional connectivity mediated the association between AEA concentrations and BMI in the AN group. However, in HC, NAcc-SMA functional connectivity had a mediating role between AEA concentrations and BMI. Although no significant differences in eCBs concentrations were observed between the groups, our findings provide insights into how the interaction between eCBs and NAcc functional connectivity influences AN severity. Altered NAcc-insula and NAcc-SMA connectivity in AN may impair the integration of interoceptive, somatosensory, and motor planning information related to reward stimuli. Furthermore, the distinct associations between eCBs concentrations and NAcc functional connectivity in AN and HC could have clinical implications for weight maintenance, with eCBs being a potential target for AN treatment.

Similares en LA Referencia