Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats
Curcumin is a natural compound obtained from turmeric root with high antioxidant and anti-inflammatory activities. However, clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation. This study was conducted to evaluate the e...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/114075 |
| Acceso en línea: | https://hdl.handle.net/10171/114075 |
| Access Level: | acceso abierto |
| Palabra clave: | Antioxidant Bioavailability Curcumin Curcuminoid Nanoparticles |
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Zein nanoparticles improve the oral bioavailability of curcumin in wistar ratsBrotons-Canto, A. (Ana)|||/items/83a504a0-d109-4aa1-a29f-0d4f497ce258Gonzalez-Navarro, C.J. (Carlos Javier)|||/items/480527b9-23db-4625-b9e0-a91f385e9a1aGil-Royo, A.G. (Ana Gloria)|||/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53Asín-Prieto, E. (Eduardo)|||/items/74098752-093d-4aa1-a1ab-9ba5d6973c85Sáiz-Abajo, M.J. (María José)|||/items/d4d7b5ff-cb6a-421f-8f67-72b3d9220880Llabrés, J.M. (Josep Manuel)|||/items/1b5dbe4f-f8d0-476e-b6af-ab5237fadcc7AntioxidantBioavailabilityCurcuminCurcuminoidNanoparticlesCurcumin is a natural compound obtained from turmeric root with high antioxidant and anti-inflammatory activities. However, clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation. This study was conducted to evaluate the effect of curcumin incorporation in zein nanoparticles on the pharmacokinetic parameters of systemic curcumin in plasma. Wistar rats were administered a single oral dose of 250 mg/kg of standard curcumin (control) or nanocurcumin (zein-based nanoparticles, Nucaps). The proposed new formulation was also compared with two commercially available curcumin complexes. Blood samples were collected at different times, and plasma levels were determined using HPLC-MS/MS. Overall, nanocurcumin (Nucaps) formulation was well tolerated and showed a 9-fold increase in oral bioavailability when compared to the standard curcumin natural extract. In addition, the nanoparticles prepared in this study demonstrated a bioavailability profile superior to that of other bioavailability-enhanced curcumin complexes currently available in the marketplace. Thus, our nanoparticle-based formulation has shown great potential as a nutraceutical for the oral administration of curcumin.MDPIDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/114075reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1140752026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats |
| title |
Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats |
| spellingShingle |
Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats Brotons-Canto, A. (Ana)|||/items/83a504a0-d109-4aa1-a29f-0d4f497ce258 Antioxidant Bioavailability Curcumin Curcuminoid Nanoparticles |
| title_short |
Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats |
| title_full |
Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats |
| title_fullStr |
Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats |
| title_full_unstemmed |
Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats |
| title_sort |
Zein nanoparticles improve the oral bioavailability of curcumin in wistar rats |
| dc.creator.none.fl_str_mv |
Brotons-Canto, A. (Ana)|||/items/83a504a0-d109-4aa1-a29f-0d4f497ce258 Gonzalez-Navarro, C.J. (Carlos Javier)|||/items/480527b9-23db-4625-b9e0-a91f385e9a1a Gil-Royo, A.G. (Ana Gloria)|||/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53 Asín-Prieto, E. (Eduardo)|||/items/74098752-093d-4aa1-a1ab-9ba5d6973c85 Sáiz-Abajo, M.J. (María José)|||/items/d4d7b5ff-cb6a-421f-8f67-72b3d9220880 Llabrés, J.M. (Josep Manuel)|||/items/1b5dbe4f-f8d0-476e-b6af-ab5237fadcc7 |
| author |
Brotons-Canto, A. (Ana)|||/items/83a504a0-d109-4aa1-a29f-0d4f497ce258 |
| author_facet |
Brotons-Canto, A. (Ana)|||/items/83a504a0-d109-4aa1-a29f-0d4f497ce258 Gonzalez-Navarro, C.J. (Carlos Javier)|||/items/480527b9-23db-4625-b9e0-a91f385e9a1a Gil-Royo, A.G. (Ana Gloria)|||/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53 Asín-Prieto, E. (Eduardo)|||/items/74098752-093d-4aa1-a1ab-9ba5d6973c85 Sáiz-Abajo, M.J. (María José)|||/items/d4d7b5ff-cb6a-421f-8f67-72b3d9220880 Llabrés, J.M. (Josep Manuel)|||/items/1b5dbe4f-f8d0-476e-b6af-ab5237fadcc7 |
| author_role |
author |
| author2 |
Gonzalez-Navarro, C.J. (Carlos Javier)|||/items/480527b9-23db-4625-b9e0-a91f385e9a1a Gil-Royo, A.G. (Ana Gloria)|||/items/f54744d1-e54a-42e1-b5d0-cbabefd3fc53 Asín-Prieto, E. (Eduardo)|||/items/74098752-093d-4aa1-a1ab-9ba5d6973c85 Sáiz-Abajo, M.J. (María José)|||/items/d4d7b5ff-cb6a-421f-8f67-72b3d9220880 Llabrés, J.M. (Josep Manuel)|||/items/1b5dbe4f-f8d0-476e-b6af-ab5237fadcc7 |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Antioxidant Bioavailability Curcumin Curcuminoid Nanoparticles |
| topic |
Antioxidant Bioavailability Curcumin Curcuminoid Nanoparticles |
| description |
Curcumin is a natural compound obtained from turmeric root with high antioxidant and anti-inflammatory activities. However, clinical application of curcumin has been limited due to its low solubility and bioavailability and rapid metabolism and degradation. This study was conducted to evaluate the effect of curcumin incorporation in zein nanoparticles on the pharmacokinetic parameters of systemic curcumin in plasma. Wistar rats were administered a single oral dose of 250 mg/kg of standard curcumin (control) or nanocurcumin (zein-based nanoparticles, Nucaps). The proposed new formulation was also compared with two commercially available curcumin complexes. Blood samples were collected at different times, and plasma levels were determined using HPLC-MS/MS. Overall, nanocurcumin (Nucaps) formulation was well tolerated and showed a 9-fold increase in oral bioavailability when compared to the standard curcumin natural extract. In addition, the nanoparticles prepared in this study demonstrated a bioavailability profile superior to that of other bioavailability-enhanced curcumin complexes currently available in the marketplace. Thus, our nanoparticle-based formulation has shown great potential as a nutraceutical for the oral administration of curcumin. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/114075 |
| url |
https://hdl.handle.net/10171/114075 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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