Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration
Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, or neurodegeneration with brain iron accumulation disorders. Mitochondrial dysfunction, lipofuscin accumulation, autophagy disruption, and fer...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/351888 |
| Acceso en línea: | http://hdl.handle.net/10261/351888 |
| Access Level: | acceso abierto |
| Palabra clave: | 4-hidroxynonenal Ferroptosis Iron Lipid peroxidation Lipofuscin Neurodegeneration Neurodegeneration with brain iron accumulation Oxidative stress PLA2G6-associated neurodegeneration |
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Vicious cycle of lipid peroxidation and iron accumulation in neurodegenerationVillalón-García, IrenePovea-Cabello, SulevaÁlvarez-Córdoba, MónicaTalaverón-Rey, MartaSuarez-Rivero, Juan M.Suárez-Carrillo, AlejandraMunuera, ManuelReche-López, DianaCilleros-Holgado, PaulaPiñero-Perez, RocíoSánchez-Alcázar, José Antonio4-hidroxynonenalFerroptosisIronLipid peroxidationLipofuscinNeurodegenerationNeurodegeneration with brain iron accumulationOxidative stressPLA2G6-associated neurodegenerationLipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, or neurodegeneration with brain iron accumulation disorders. Mitochondrial dysfunction, lipofuscin accumulation, autophagy disruption, and ferroptosis have been implicated as the critical pathomechanisms of lipid peroxidation and iron accumulation in these disorders. Currently, the connection between lipid peroxidation and iron accumulation and the initial cause or consequence in neurodegeneration processes is unclear. In this review, we have compiled the known mechanisms by which lipid peroxidation triggers iron accumulation and lipofuscin formation, and the effect of iron overload on lipid peroxidation and cellular function. The vicious cycle established between both pathological alterations may lead to the development of neurodegeneration. Therefore, the investigation of these mechanisms is essential for exploring therapeutic strategies to restrict neurodegeneration. In addition, we discuss the interplay between lipid peroxidation and iron accumulation in neurodegeneration, particularly in PLA2G6-associated neurodegeneration, a rare neurodegenerative disease with autosomal recessive inheritance, which belongs to the group of neurodegeneration with brain iron accumulation disorders.This work was supported by FIS PI16/00786 (2016) and FIS PI19/00377 (2019) grants, the Ministerio de Sanidad, Spain and the Fondo Europeo de Desarrollo Regional (FEDER Unión Europea), Spanish Ministry of Education, Culture and Sport. This activity has been co-financed by the European Regional Development Fund (ERDF) and by the Regional Ministry of Economic Transformation, Industry, Knowledge and Universities of the Junta de Andalucía, within the framework of the ERDF Andalusia operational program 2014-2020 Thematic objective “01 - Reinforcement of research, technological development and innovation” through the reference research project CTS-5725 and PY18-850 (to JASA)Peer reviewedMedknow PublicationsMinisterio de Sanidad (España)European CommissionMinisterio de Educación, Cultura y Deporte (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/351888reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.4103/1673-5374.358614Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3518882026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration |
| title |
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration |
| spellingShingle |
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration Villalón-García, Irene 4-hidroxynonenal Ferroptosis Iron Lipid peroxidation Lipofuscin Neurodegeneration Neurodegeneration with brain iron accumulation Oxidative stress PLA2G6-associated neurodegeneration |
| title_short |
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration |
| title_full |
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration |
| title_fullStr |
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration |
| title_full_unstemmed |
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration |
| title_sort |
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration |
| dc.creator.none.fl_str_mv |
Villalón-García, Irene Povea-Cabello, Suleva Álvarez-Córdoba, Mónica Talaverón-Rey, Marta Suarez-Rivero, Juan M. Suárez-Carrillo, Alejandra Munuera, Manuel Reche-López, Diana Cilleros-Holgado, Paula Piñero-Perez, Rocío Sánchez-Alcázar, José Antonio |
| author |
Villalón-García, Irene |
| author_facet |
Villalón-García, Irene Povea-Cabello, Suleva Álvarez-Córdoba, Mónica Talaverón-Rey, Marta Suarez-Rivero, Juan M. Suárez-Carrillo, Alejandra Munuera, Manuel Reche-López, Diana Cilleros-Holgado, Paula Piñero-Perez, Rocío Sánchez-Alcázar, José Antonio |
| author_role |
author |
| author2 |
Povea-Cabello, Suleva Álvarez-Córdoba, Mónica Talaverón-Rey, Marta Suarez-Rivero, Juan M. Suárez-Carrillo, Alejandra Munuera, Manuel Reche-López, Diana Cilleros-Holgado, Paula Piñero-Perez, Rocío Sánchez-Alcázar, José Antonio |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Sanidad (España) European Commission Ministerio de Educación, Cultura y Deporte (España) Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
4-hidroxynonenal Ferroptosis Iron Lipid peroxidation Lipofuscin Neurodegeneration Neurodegeneration with brain iron accumulation Oxidative stress PLA2G6-associated neurodegeneration |
| topic |
4-hidroxynonenal Ferroptosis Iron Lipid peroxidation Lipofuscin Neurodegeneration Neurodegeneration with brain iron accumulation Oxidative stress PLA2G6-associated neurodegeneration |
| description |
Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, or neurodegeneration with brain iron accumulation disorders. Mitochondrial dysfunction, lipofuscin accumulation, autophagy disruption, and ferroptosis have been implicated as the critical pathomechanisms of lipid peroxidation and iron accumulation in these disorders. Currently, the connection between lipid peroxidation and iron accumulation and the initial cause or consequence in neurodegeneration processes is unclear. In this review, we have compiled the known mechanisms by which lipid peroxidation triggers iron accumulation and lipofuscin formation, and the effect of iron overload on lipid peroxidation and cellular function. The vicious cycle established between both pathological alterations may lead to the development of neurodegeneration. Therefore, the investigation of these mechanisms is essential for exploring therapeutic strategies to restrict neurodegeneration. In addition, we discuss the interplay between lipid peroxidation and iron accumulation in neurodegeneration, particularly in PLA2G6-associated neurodegeneration, a rare neurodegenerative disease with autosomal recessive inheritance, which belongs to the group of neurodegeneration with brain iron accumulation disorders. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_dcae04bc Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/351888 |
| url |
http://hdl.handle.net/10261/351888 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
https://doi.org/10.4103/1673-5374.358614 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Medknow Publications |
| publisher.none.fl_str_mv |
Medknow Publications |
| dc.source.none.fl_str_mv |
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
| instname_str |
Consejo Superior de Investigaciones Científicas (CSIC) |
| reponame_str |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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