Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes,...

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Detalhes bibliográficos
Autores: Stockwell, Brent R, Friedmann Angeli, José Pedro, Bayir, Hülya, Bush, Ashley I, Conrad, Marcus, Dixon, Scott J, Fulda, Simone, Gascón, Sergio, Hatzios, Stavroula K, Kagan, Valerian E, Noel, Kay, Jiang, Xuejun, Linkermann, Andreas, Murphy, Maureen E, Overholtzer, Michael, Oyagi, Atsushi, Pagnussat, Gabriela C, Park, Jason, Ran, Qitao, Rosenfeld, Craig S, Salnikow, Konstantin, Tang, Daolin, Torti, Frank M, Torti, Suzy V, Toyokuni, Shinya, Woerpel, K A, Zhang, Donna D
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/346444
Acesso em linha:http://hdl.handle.net/10261/346444
https://api.elsevier.com/content/abstract/scopus_id/85030552365
Access Level:acceso abierto
Palavra-chave:PUFA
ROS
cancer
cell death
ferroptosis
glutathione
iron
metabolism
neurodegeneration
peroxidation
Descrição
Resumo:Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron, and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH, and coenzyme Q10. Ferroptosis has been implicated in the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Huntington's, and Parkinson's diseases), carcinogenesis, stroke, intracerebral hemorrhage, traumatic brain injury, ischemia-reperfusion injury, and kidney degeneration in mammals and is also implicated in heat stress in plants. Ferroptosis may also have a tumor-suppressor function that could be harnessed for cancer therapy. This Primer reviews the mechanisms underlying ferroptosis, highlights connections to other areas of biology and medicine, and recommends tools and guidelines for studying this emerging form of regulated cell death.

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