MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice

Background and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders...

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Autores: Garcia, DS, Sauco, MA, Calopa, M, Carrillo, F, Sevilla, FE, Freire, E, Ramos, RG, Kulisevsky, J, Esteban, JCG, Legarda, I, Luquin, MRI, Castrillo, JCM, Martinez-Martin, P, Martinez-Torres, I, Mir, P, Ignacio, AS
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositório:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p13761
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/13761
Access Level:Acceso aberto
Palavra-chave:cognition
dependency
non-motor symptoms
motor symptoms
Parkinson's disease
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spelling MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical PracticeGarcia, DSSauco, MACalopa, MCarrillo, FSevilla, FEFreire, ERamos, RGKulisevsky, JEsteban, JCGLegarda, ILuquin, MRICastrillo, JCMMartinez-Martin, PMartinez-Torres, IMir, PIgnacio, AScognitiondependencynon-motor symptomsmotor symptomsParkinson's diseaseBackground and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results: The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions: A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/13761DiagnosticsISSN: 20754418reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p137612026-06-11T12:45:17Z
dc.title.none.fl_str_mv MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
title MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
spellingShingle MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
Garcia, DS
cognition
dependency
non-motor symptoms
motor symptoms
Parkinson's disease
title_short MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
title_full MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
title_fullStr MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
title_full_unstemmed MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
title_sort MNCD: A New Tool for Classifying Parkinson's Disease in Daily Clinical Practice
dc.creator.none.fl_str_mv Garcia, DS
Sauco, MA
Calopa, M
Carrillo, F
Sevilla, FE
Freire, E
Ramos, RG
Kulisevsky, J
Esteban, JCG
Legarda, I
Luquin, MRI
Castrillo, JCM
Martinez-Martin, P
Martinez-Torres, I
Mir, P
Ignacio, AS
author Garcia, DS
author_facet Garcia, DS
Sauco, MA
Calopa, M
Carrillo, F
Sevilla, FE
Freire, E
Ramos, RG
Kulisevsky, J
Esteban, JCG
Legarda, I
Luquin, MRI
Castrillo, JCM
Martinez-Martin, P
Martinez-Torres, I
Mir, P
Ignacio, AS
author_role author
author2 Sauco, MA
Calopa, M
Carrillo, F
Sevilla, FE
Freire, E
Ramos, RG
Kulisevsky, J
Esteban, JCG
Legarda, I
Luquin, MRI
Castrillo, JCM
Martinez-Martin, P
Martinez-Torres, I
Mir, P
Ignacio, AS
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv cognition
dependency
non-motor symptoms
motor symptoms
Parkinson's disease
topic cognition
dependency
non-motor symptoms
motor symptoms
Parkinson's disease
description Background and objective: Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods: Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results: The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions: A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/13761
url https://fisabio.portalinvestigacion.com/publicaciones/13761
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Diagnostics
ISSN: 20754418
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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