MNCD

Background and objective : Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods : Sixteen movement disorde...

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Detalles Bibliográficos
Autores: Santos García, Diego|||0000-0002-3126-5111, Álvarez Sauco, María, Calopa, Matilde|||0000-0002-6943-3707, Carrillo, Fátima, Escamilla Sevilla, Francisco|||0000-0003-2149-2668, Freire, Eric, García Ramos, Rocío, Kulisevsky, Jaime|||0000-0003-4870-1431, Gómez Esteban, Juan Carlos|||0000-0002-4697-3890, Legarda, Inés, Luquin, Maria-Rosario|||0000-0002-5594-1794, Martínez-Castrillo, Juan Carlos|||0000-0001-7744-6850, Martínez-Martin, Pablo, Martínez-Torres, Irene|||0000-0003-3081-5836, Mir, Pablo|||0000-0003-1656-302X, Ignacio, Ángel Sesar
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:251702
Acceso en línea:https://ddd.uab.cat/record/251702
https://dx.doi.org/urn:doi:10.3390/diagnostics12010055
Access Level:acceso abierto
Palabra clave:Cognition
Dependency
Non-motor symptoms
Motor symptoms
Parkinson's disease
Descripción
Sumario:Background and objective : Parkinson's disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key symptoms and staging in PD. Patients and Methods : Sixteen movement disorders specialists from Spain participated in this project. The classification was consensually approved after a discussion and review process from June to October 2021. The TNM classification and the National Institutes of Health Stroke Scale (NIHSS) were considered as models in the design. Results : The classification was named MNCD and included 4 major axes: (1) motor symptoms; (2) non-motor symptoms; (3) cognition; (4) dependency for activities of daily living (ADL). Motor axis included 4 sub-axes: (1) motor fluctuations; (2) dyskinesia; (3) axial symptoms; (4) tremor. Four other sub-axes were included in the non-motor axis: (1) neuropsychiatric symptoms; (2) autonomic dysfunction; (3) sleep disturbances and fatigue; (4) pain and sensory disorders. According to the MNCD, 5 stages were considered, from stage 1 (no disabling motor or non-motor symptoms with normal cognition and independency for ADL) to 5 (dementia and dependency for basic ADL). Conclusions : A new simple classification of PD is proposed. The MNCD classification includes 4 major axes and 5 stages to identify key symptoms and monitor the evolution of the disease in patients with PD. It is necessary to apply this proof of concept in a properly designed study.

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