Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors

Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geom...

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Autores: Álvarez Molina, Rafael, Muñoz-Piña, Sandra, González, María U., Izquierdo-Barba, Isabel, Fernández-Martínez, Iván, Rico-Gavira, Víctor Joaquín, Arcos, Daniel, García-Valenzuela, Aurelio, Palmero Acebedo, Alberto, Vallet-Regí, María, Rodríguez González-Elipe, Agustín, García-Martín, José María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/93617
Acceso en línea:https://hdl.handle.net/11441/93617
https://doi.org/10.3390/nano9091217
Access Level:acceso abierto
Palabra clave:Magnetron sputtering
Oblique angle deposition
Nanostructured titanium thin films
Antibacterial coatings
Osteoblast proliferation
Industrial scale
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spelling Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial ReactorsÁlvarez Molina, RafaelMuñoz-Piña, SandraGonzález, María U.Izquierdo-Barba, IsabelFernández-Martínez, IvánRico-Gavira, Víctor JoaquínArcos, DanielGarcía-Valenzuela, AurelioPalmero Acebedo, AlbertoVallet-Regí, MaríaRodríguez González-Elipe, AgustínGarcía-Martín, José MaríaMagnetron sputteringOblique angle depositionNanostructured titanium thin filmsAntibacterial coatingsOsteoblast proliferationIndustrial scaleBased on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (DePuy Synthes) and a pseudo-rectangular bone plate extracted from a patient were coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments were performed: Analysis of bacterial adhesion and biofilm formation, and osteoblasts–bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior toward osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings.EU-FEDER and the MINECO-AEI 201560E055EU-FEDER and the MINECO-AEI MAT2014-59772-C2-1-PEU-FEDER and the MINECO-AEI MAT2016-75611-REU-FEDER and the MINECO-AEI MAT2016-79866-REU-FEDER and the MINECO-AEI MAT2015-69035-REDCUniversity of Seville (Spain) V and VI PPIT-USMINECO CSIC13-4E-1794MDPIFísica Aplicada IQuímica InorgánicaFQM196: Nanotecnología en Superficies y Plasma2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/93617https://doi.org/10.3390/nano9091217reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésNanomaterials, 9 (9), 1217-.AEI 201560E055MAT2014-59772-C2-1-PMAT2016-75611-RMAT2016-79866-RMAT2015-69035-REDCCSIC13-4E-1794https://www.mdpi.com/2079-4991/9/9/1217info:eu-repo/semantics/openAccessoai:idus.us.es:11441/936172026-06-17T12:51:07Z
dc.title.none.fl_str_mv Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors
title Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors
spellingShingle Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors
Álvarez Molina, Rafael
Magnetron sputtering
Oblique angle deposition
Nanostructured titanium thin films
Antibacterial coatings
Osteoblast proliferation
Industrial scale
title_short Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors
title_full Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors
title_fullStr Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors
title_full_unstemmed Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors
title_sort Antibacterial Nanostructured Ti Coatings by Magnetron Sputtering: From Laboratory Scales to Industrial Reactors
dc.creator.none.fl_str_mv Álvarez Molina, Rafael
Muñoz-Piña, Sandra
González, María U.
Izquierdo-Barba, Isabel
Fernández-Martínez, Iván
Rico-Gavira, Víctor Joaquín
Arcos, Daniel
García-Valenzuela, Aurelio
Palmero Acebedo, Alberto
Vallet-Regí, María
Rodríguez González-Elipe, Agustín
García-Martín, José María
author Álvarez Molina, Rafael
author_facet Álvarez Molina, Rafael
Muñoz-Piña, Sandra
González, María U.
Izquierdo-Barba, Isabel
Fernández-Martínez, Iván
Rico-Gavira, Víctor Joaquín
Arcos, Daniel
García-Valenzuela, Aurelio
Palmero Acebedo, Alberto
Vallet-Regí, María
Rodríguez González-Elipe, Agustín
García-Martín, José María
author_role author
author2 Muñoz-Piña, Sandra
González, María U.
Izquierdo-Barba, Isabel
Fernández-Martínez, Iván
Rico-Gavira, Víctor Joaquín
Arcos, Daniel
García-Valenzuela, Aurelio
Palmero Acebedo, Alberto
Vallet-Regí, María
Rodríguez González-Elipe, Agustín
García-Martín, José María
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Física Aplicada I
Química Inorgánica
FQM196: Nanotecnología en Superficies y Plasma
dc.subject.none.fl_str_mv Magnetron sputtering
Oblique angle deposition
Nanostructured titanium thin films
Antibacterial coatings
Osteoblast proliferation
Industrial scale
topic Magnetron sputtering
Oblique angle deposition
Nanostructured titanium thin films
Antibacterial coatings
Osteoblast proliferation
Industrial scale
description Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the required growth conditions in a laboratory setup, a new geometry and methodology have been proposed and tested in a semi-industrial scale reactor. A bone plate (DePuy Synthes) and a pseudo-rectangular bone plate extracted from a patient were coated following the new methodology, obtaining that their osteoblast proliferation efficiency and antibacterial functionality were equivalent to the coatings grown in the laboratory reactor on small areas. In particular, two kinds of experiments were performed: Analysis of bacterial adhesion and biofilm formation, and osteoblasts–bacteria competitive in vitro growth scenarios. In all these cases, the coatings show an opposite behavior toward osteoblast and bacterial proliferation, demonstrating that the proposed methodology represents a valid approach for industrial production and practical application of nanostructured titanium coatings.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/93617
https://doi.org/10.3390/nano9091217
url https://hdl.handle.net/11441/93617
https://doi.org/10.3390/nano9091217
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nanomaterials, 9 (9), 1217-.
AEI 201560E055
MAT2014-59772-C2-1-P
MAT2016-75611-R
MAT2016-79866-R
MAT2015-69035-REDC
CSIC13-4E-1794
https://www.mdpi.com/2079-4991/9/9/1217
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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