Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds

In the present work, several MEEKC systems are studied to assess their suitability for lipophilicity determination of acidic, neutral, and basic compounds. Thus, several microemulsion compositions over a wide range of pH values (from 2.0 to 12.0), containing heptane, 1−butanol and different types an...

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Autores: Subirats i Vila, Xavier, Yuan, Hui-Ping, Chaves, Verónica, Marzal, Núria, Rosés Pascual, Martí
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/101321
Acesso em linha:https://hdl.handle.net/2445/101321
Access Level:acceso abierto
Palavra-chave:Electroforesi capil·lar
Cromatografia de líquids
Lipofília
Capillary electrophoresis
Liquid chromatography
Lipophilicity
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spelling Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compoundsSubirats i Vila, XavierYuan, Hui-PingChaves, VerónicaMarzal, NúriaRosés Pascual, MartíElectroforesi capil·larCromatografia de líquidsLipofíliaCapillary electrophoresisLiquid chromatographyLipophilicityIn the present work, several MEEKC systems are studied to assess their suitability for lipophilicity determination of acidic, neutral, and basic compounds. Thus, several microemulsion compositions over a wide range of pH values (from 2.0 to 12.0), containing heptane, 1−butanol and different types and amounts of surfactant (SDS or sodium cholate: from 1.3 to 3.3%) are characterized using Abraham's solvation model. The addition of acetonitrile (up to 10%) is also studied, since it increases the resolution of the technique for the most lipophilic compounds. The system coefficients obtained are very similar to those of the 1−octanol/water, used as the reference lipophilicity index, allowing simple and linear correlations between the 1−octanol/water partition values (log Po/w) and MEEKC mass distribution ratios (log kMEEKC). Variations in the microemulsion composition (aqueous buffer, surfactant, concentration of ACN) did not significantly affect the similarity of the MEEKC systems to log Po/w partition.Wiley-VCH2016201720162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion7 p.application/pdfhttps://hdl.handle.net/2445/101321Articles publicats en revistes (Enginyeria Química i Química Analítica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: http://dx.doi.org/10.1002/elps.201600080Electrophoresis, 2016, vol. 37, num. 14, p. 2010-2016http://dx.doi.org/10.1002/elps.201600080(c) Wiley-VCH, 2016info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1013212026-05-29T05:05:01Z
dc.title.none.fl_str_mv Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds
title Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds
spellingShingle Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds
Subirats i Vila, Xavier
Electroforesi capil·lar
Cromatografia de líquids
Lipofília
Capillary electrophoresis
Liquid chromatography
Lipophilicity
title_short Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds
title_full Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds
title_fullStr Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds
title_full_unstemmed Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds
title_sort Microemulsion electrokinetic chromatography as a suitable tool for lipophilicity determination of acidic, neutral, and basic compounds
dc.creator.none.fl_str_mv Subirats i Vila, Xavier
Yuan, Hui-Ping
Chaves, Verónica
Marzal, Núria
Rosés Pascual, Martí
author Subirats i Vila, Xavier
author_facet Subirats i Vila, Xavier
Yuan, Hui-Ping
Chaves, Verónica
Marzal, Núria
Rosés Pascual, Martí
author_role author
author2 Yuan, Hui-Ping
Chaves, Verónica
Marzal, Núria
Rosés Pascual, Martí
author2_role author
author
author
author
dc.subject.none.fl_str_mv Electroforesi capil·lar
Cromatografia de líquids
Lipofília
Capillary electrophoresis
Liquid chromatography
Lipophilicity
topic Electroforesi capil·lar
Cromatografia de líquids
Lipofília
Capillary electrophoresis
Liquid chromatography
Lipophilicity
description In the present work, several MEEKC systems are studied to assess their suitability for lipophilicity determination of acidic, neutral, and basic compounds. Thus, several microemulsion compositions over a wide range of pH values (from 2.0 to 12.0), containing heptane, 1−butanol and different types and amounts of surfactant (SDS or sodium cholate: from 1.3 to 3.3%) are characterized using Abraham's solvation model. The addition of acetonitrile (up to 10%) is also studied, since it increases the resolution of the technique for the most lipophilic compounds. The system coefficients obtained are very similar to those of the 1−octanol/water, used as the reference lipophilicity index, allowing simple and linear correlations between the 1−octanol/water partition values (log Po/w) and MEEKC mass distribution ratios (log kMEEKC). Variations in the microemulsion composition (aqueous buffer, surfactant, concentration of ACN) did not significantly affect the similarity of the MEEKC systems to log Po/w partition.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/101321
url https://hdl.handle.net/2445/101321
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1002/elps.201600080
Electrophoresis, 2016, vol. 37, num. 14, p. 2010-2016
http://dx.doi.org/10.1002/elps.201600080
dc.rights.none.fl_str_mv (c) Wiley-VCH, 2016
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wiley-VCH, 2016
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Química i Química Analítica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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