Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides

Catalysts generated by combinations of Pd(TFA)and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids toN-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding a-aryl a-hydrazino esters/amides in high enantioselectivities. Subsequent removal...

Descripción completa

Detalles Bibliográficos
Autores: Velázquez, Marta, Alberca, Saúl, Iglesias-Sigüenza, Javier, Fernández, Rosario, Lassaletta, José M., Monge, David
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/219719
Acceso en línea:http://hdl.handle.net/10261/219719
Access Level:acceso abierto
id ES_b9c3fc78ddbf4f323f8f8a63e78805aa
oai_identifier_str oai:digital.csic.es:10261/219719
network_acronym_str ES
network_name_str España
repository_id_str
spelling Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amidesVelázquez, MartaAlberca, SaúlIglesias-Sigüenza, JavierFernández, RosarioLassaletta, José M.Monge, DavidCatalysts generated by combinations of Pd(TFA)and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids toN-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding a-aryl a-hydrazino esters/amides in high enantioselectivities. Subsequent removal of the carbamoyl moiety affords key building blocks en route to hydrazinopeptides,N-aminopeptides and peptidomimetics thereof.Royal Society of Chemistry (UK)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/219719reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1039/d0cc02478cSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2197192026-05-22T06:33:51Z
dc.title.none.fl_str_mv Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
title Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
spellingShingle Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
Velázquez, Marta
title_short Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
title_full Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
title_fullStr Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
title_full_unstemmed Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
title_sort Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
dc.creator.none.fl_str_mv Velázquez, Marta
Alberca, Saúl
Iglesias-Sigüenza, Javier
Fernández, Rosario
Lassaletta, José M.
Monge, David
author Velázquez, Marta
author_facet Velázquez, Marta
Alberca, Saúl
Iglesias-Sigüenza, Javier
Fernández, Rosario
Lassaletta, José M.
Monge, David
author_role author
author2 Alberca, Saúl
Iglesias-Sigüenza, Javier
Fernández, Rosario
Lassaletta, José M.
Monge, David
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Catalysts generated by combinations of Pd(TFA)and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids toN-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding a-aryl a-hydrazino esters/amides in high enantioselectivities. Subsequent removal of the carbamoyl moiety affords key building blocks en route to hydrazinopeptides,N-aminopeptides and peptidomimetics thereof.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/219719
url http://hdl.handle.net/10261/219719
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1039/d0cc02478c
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society of Chemistry (UK)
publisher.none.fl_str_mv Royal Society of Chemistry (UK)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417800829763584
score 15,812429

Similares en LA Referencia