Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases

Neurodegenerative diseases affect millions of people worldwide and include a wide variety of pathologies such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease among others. Although there is no cure for these pathologies, natural compounds have emerged as a suitable alternative...

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Authors: Bonilla, Lorena, Esteruelas, Gerard, Ettcheto, Miren, Gómara, María José, Haro Villar, Isabel, Souto, Eliana B., Espina, Marta, Camins, Antonio, García, M. Luisa, Cano, Amanda, Sánchez-López, Elena
Format: other
Status:Versión aceptada para publicación
Publication Date:2024
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/370567
Online Access:http://hdl.handle.net/10261/370567
https://api.elsevier.com/content/abstract/scopus_id/85206417493
Access Level:Open access
Keyword:Peptide amphiphiles
Blood-brain barrier
Brain drug delivery
Liposomes
Nanoparticles
Neurodegeneration
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative DiseasesBonilla, LorenaEsteruelas, GerardEttcheto, MirenGómara, María JoséHaro Villar, IsabelSouto, Eliana B.Espina, MartaCamins, AntonioGarcía, M. LuisaCano, AmandaSánchez-López, ElenaPeptide amphiphilesBlood-brain barrierBrain drug deliveryLiposomesNanoparticlesNeurodegenerationhttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesNeurodegenerative diseases affect millions of people worldwide and include a wide variety of pathologies such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease among others. Although there is no cure for these pathologies, natural compounds have emerged as a suitable alternative against currently used drugs since they possess increased biocompatibility and suitable pharmacological properties. However, the presence of the blood-brain barrier (BBB) limits the action of these molecules and makes their delivery to the brain a great challenge. To minimize this problem and enhance drug delivery into the brain with an effective therapeutic dose, the use of nanomedicine has shown great potential. In this sense, nanocarriers can deliver natural compounds to the brain overcoming the BBB and achieving therapeutic doses on the target site. In this area, biodegradable and biocompatible nanocarriers constitute suitable vehicles to deliver the active compounds. Among them, polymeric and lipid nanoparticlPeer reviewedSpringerConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248Postprintinfo:eu-repo/semantics/acceptedVersioninfo:eu-repo/semantics/bookParthttp://hdl.handle.net/10261/370567https://api.elsevier.com/content/abstract/scopus_id/85206417493reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésDrug Delivery Strategies in Neurological Disorders: Challenges and Opportunitieshttps://doi.org/10.1007/978-981-99-6807-7_18Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3705672026-05-22T06:33:51Z
dc.title.none.fl_str_mv Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
title Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
spellingShingle Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
Bonilla, Lorena
Peptide amphiphiles
Blood-brain barrier
Brain drug delivery
Liposomes
Nanoparticles
Neurodegeneration
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
title_full Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
title_fullStr Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
title_full_unstemmed Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
title_sort Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
dc.creator.none.fl_str_mv Bonilla, Lorena
Esteruelas, Gerard
Ettcheto, Miren
Gómara, María José
Haro Villar, Isabel
Souto, Eliana B.
Espina, Marta
Camins, Antonio
García, M. Luisa
Cano, Amanda
Sánchez-López, Elena
author Bonilla, Lorena
author_facet Bonilla, Lorena
Esteruelas, Gerard
Ettcheto, Miren
Gómara, María José
Haro Villar, Isabel
Souto, Eliana B.
Espina, Marta
Camins, Antonio
García, M. Luisa
Cano, Amanda
Sánchez-López, Elena
author_role author
author2 Esteruelas, Gerard
Ettcheto, Miren
Gómara, María José
Haro Villar, Isabel
Souto, Eliana B.
Espina, Marta
Camins, Antonio
García, M. Luisa
Cano, Amanda
Sánchez-López, Elena
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Peptide amphiphiles
Blood-brain barrier
Brain drug delivery
Liposomes
Nanoparticles
Neurodegeneration
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Peptide amphiphiles
Blood-brain barrier
Brain drug delivery
Liposomes
Nanoparticles
Neurodegeneration
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description Neurodegenerative diseases affect millions of people worldwide and include a wide variety of pathologies such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease among others. Although there is no cure for these pathologies, natural compounds have emerged as a suitable alternative against currently used drugs since they possess increased biocompatibility and suitable pharmacological properties. However, the presence of the blood-brain barrier (BBB) limits the action of these molecules and makes their delivery to the brain a great challenge. To minimize this problem and enhance drug delivery into the brain with an effective therapeutic dose, the use of nanomedicine has shown great potential. In this sense, nanocarriers can deliver natural compounds to the brain overcoming the BBB and achieving therapeutic doses on the target site. In this area, biodegradable and biocompatible nanocarriers constitute suitable vehicles to deliver the active compounds. Among them, polymeric and lipid nanoparticl
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
Postprint
info:eu-repo/semantics/acceptedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/370567
https://api.elsevier.com/content/abstract/scopus_id/85206417493
url http://hdl.handle.net/10261/370567
https://api.elsevier.com/content/abstract/scopus_id/85206417493
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities
https://doi.org/10.1007/978-981-99-6807-7_18
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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