Drug Delivery Strategies for the Administration of Natural Compounds to the Brain in Neurodegenerative Diseases
Neurodegenerative diseases affect millions of people worldwide and include a wide variety of pathologies such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease among others. Although there is no cure for these pathologies, natural compounds have emerged as a suitable alternative...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | otro |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/370567 |
| Acceso en línea: | http://hdl.handle.net/10261/370567 https://api.elsevier.com/content/abstract/scopus_id/85206417493 |
| Access Level: | acceso abierto |
| Palabra clave: | Peptide amphiphiles Blood-brain barrier Brain drug delivery Liposomes Nanoparticles Neurodegeneration http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages |
| Sumario: | Neurodegenerative diseases affect millions of people worldwide and include a wide variety of pathologies such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease among others. Although there is no cure for these pathologies, natural compounds have emerged as a suitable alternative against currently used drugs since they possess increased biocompatibility and suitable pharmacological properties. However, the presence of the blood-brain barrier (BBB) limits the action of these molecules and makes their delivery to the brain a great challenge. To minimize this problem and enhance drug delivery into the brain with an effective therapeutic dose, the use of nanomedicine has shown great potential. In this sense, nanocarriers can deliver natural compounds to the brain overcoming the BBB and achieving therapeutic doses on the target site. In this area, biodegradable and biocompatible nanocarriers constitute suitable vehicles to deliver the active compounds. Among them, polymeric and lipid nanoparticl |
|---|