Deleterious effect of trimethoprim-sulfamethoxazole in Mediterranean spotted fever

[EN]In a series of 10 patients with Mediterranean spotted fever (MSF) (two of whom developed severe forms of the disease), trimethoprim-sulfamethoxazole (TS) was not an effective therapy; moreover, it appeared the drug increased the pathogenic potential of R. cononii. In the opinion of the authors a...

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Bibliographic Details
Authors: Ruiz Beltrán, R., Herrero Herrero, José Ignacio
Format: article
Status:Published version
Publication Date:1992
Country:España
Institution:Universidad de Salamanca (USAL)
Repository:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/169203
Online Access:http://hdl.handle.net/10366/169203
Access Level:Open access
Keyword:Trimethoprim-sulfamethoxazole
Mediterranean spotted fever
Boutonneuse fever
Rickettsia conorii infection
Aged
Trimethoprim
Boutonneuse Fever
Humans
32 Ciencias Médicas
humanos
anciano
fiebre botonosa
trimetoprim
Description
Summary:[EN]In a series of 10 patients with Mediterranean spotted fever (MSF) (two of whom developed severe forms of the disease), trimethoprim-sulfamethoxazole (TS) was not an effective therapy; moreover, it appeared the drug increased the pathogenic potential of R. cononii. In the opinion of the authors and according to these results, TS cannot be considered an effective therapy for MSF.