Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for...

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Detalhes bibliográficos
Autores: Legarda Ceballos, Ana L., del Olmo, Esther, López-Abán, Julio, Escarcena, Ricardo, Bustos, Luis A., Fonseca Berzal, Cristina Rosa, Gómez Barrio, Alicia, Dib, Juan, San Feliciano, Arturo, Muro, Antonio
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/23897
Acesso em linha:https://hdl.handle.net/20.500.14352/23897
Access Level:acceso abierto
Palavra-chave:576.8
aminoalcohols
diamines
Trypanosoma cruzi
epimastigotes
amastigotes
cytotoxicity
Parasitología (Farmacia)
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oai_identifier_str oai:docta.ucm.es:20.500.14352/23897
network_acronym_str ES
network_name_str España
repository_id_str
spelling Trypanocidal Activity of Long Chain Diamines and AminoalcoholsLegarda Ceballos, Ana L.del Olmo, EstherLópez-Abán, JulioEscarcena, RicardoBustos, Luis A.Fonseca Berzal, Cristina RosaGómez Barrio, AliciaDib, JuanSan Feliciano, ArturoMuro, Antonio576.8aminoalcoholsdiaminesTrypanosoma cruziepimastigotesamastigotescytotoxicityParasitología (Farmacia)Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.MDPIUniversidad Complutense de Madrid20152015-06-2320152015-06-23journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/23897reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/238972026-06-02T12:44:21Z
dc.title.none.fl_str_mv Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
title Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
spellingShingle Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
Legarda Ceballos, Ana L.
576.8
aminoalcohols
diamines
Trypanosoma cruzi
epimastigotes
amastigotes
cytotoxicity
Parasitología (Farmacia)
title_short Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
title_full Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
title_fullStr Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
title_full_unstemmed Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
title_sort Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
dc.creator.none.fl_str_mv Legarda Ceballos, Ana L.
del Olmo, Esther
López-Abán, Julio
Escarcena, Ricardo
Bustos, Luis A.
Fonseca Berzal, Cristina Rosa
Gómez Barrio, Alicia
Dib, Juan
San Feliciano, Arturo
Muro, Antonio
author Legarda Ceballos, Ana L.
author_facet Legarda Ceballos, Ana L.
del Olmo, Esther
López-Abán, Julio
Escarcena, Ricardo
Bustos, Luis A.
Fonseca Berzal, Cristina Rosa
Gómez Barrio, Alicia
Dib, Juan
San Feliciano, Arturo
Muro, Antonio
author_role author
author2 del Olmo, Esther
López-Abán, Julio
Escarcena, Ricardo
Bustos, Luis A.
Fonseca Berzal, Cristina Rosa
Gómez Barrio, Alicia
Dib, Juan
San Feliciano, Arturo
Muro, Antonio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 576.8
aminoalcohols
diamines
Trypanosoma cruzi
epimastigotes
amastigotes
cytotoxicity
Parasitología (Farmacia)
topic 576.8
aminoalcohols
diamines
Trypanosoma cruzi
epimastigotes
amastigotes
cytotoxicity
Parasitología (Farmacia)
description Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-06-23
2015
2015-06-23
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/23897
url https://hdl.handle.net/20.500.14352/23897
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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