Synthesis, biophysical and biological evaluation of N -phenylbenzamidederivatives targeting the mitochondrial DNA of kinetoplastid parasites
Kinetoplastid parasites are responsible for three most common and neglected vector-bornehuman diseases, which are the focus of this Thesis: leishmaniasis, which is caused byLeishmania spp., human African trypanosomiasis caused by Trypanosoma brucei spp., andChagas disease caused by Trypanosoma cruzi...
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| Format: | doctoral thesis |
| Publication Date: | 2023 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | English |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/4121 |
| Online Access: | https://hdl.handle.net/20.500.14352/4121 |
| Access Level: | Open access |
| Keyword: | 576.8(043.2) Parasites Parásitos Parasitología (Farmacia) |
| Summary: | Kinetoplastid parasites are responsible for three most common and neglected vector-bornehuman diseases, which are the focus of this Thesis: leishmaniasis, which is caused byLeishmania spp., human African trypanosomiasis caused by Trypanosoma brucei spp., andChagas disease caused by Trypanosoma cruzi. All of them display high morbidity and mortalityrates mainly in developing countries.Kinetoplastid parasites are characterised by the presence of a disk-shaped mitochondrial DNA,named as “kinetoplast DNA” (kDNA), comprising > 70% AT base pairs. Kinetoplastid cellshapes change during the complex differentiation processes that occur in their life cycles. Thesedifferentiations are key to the successful transfer of the parasite between vector and host, andvice versa.Despite the social and economic burden of kinetoplastid diseases, the chemotherapeutic arsenalto treat them remains underdeveloped. Hence, there is an urgent need for new safeantitrypanosomal and leishmanicidal treatments... |
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