Complement as a Therapeutic Target in Systemic Autoimmune Diseases

The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune respons...

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Detalles Bibliográficos
Autores: Galindo Izquierdo, María, Pablos Álvarez, José Luis
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/7131
Acceso en línea:https://hdl.handle.net/20.500.14352/7131
Access Level:acceso abierto
Palabra clave:complement system
pathogenesis
therapeutic blockade
rheumatic autoimmune diseases
Reumatología
3205.09 Reumatología
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spelling Complement as a Therapeutic Target in Systemic Autoimmune DiseasesGalindo Izquierdo, MaríaPablos Álvarez, José Luiscomplement systempathogenesistherapeutic blockaderheumatic autoimmune diseasesReumatología3205.09 ReumatologíaThe complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune processes in which complement plays a pathogenic role and its potential relevance as a therapeutic target.MPDIUniversidad Complutense de Madrid20212021-01-1320212021-01-13journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/7131reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/71312026-06-02T12:44:21Z
dc.title.none.fl_str_mv Complement as a Therapeutic Target in Systemic Autoimmune Diseases
title Complement as a Therapeutic Target in Systemic Autoimmune Diseases
spellingShingle Complement as a Therapeutic Target in Systemic Autoimmune Diseases
Galindo Izquierdo, María
complement system
pathogenesis
therapeutic blockade
rheumatic autoimmune diseases
Reumatología
3205.09 Reumatología
title_short Complement as a Therapeutic Target in Systemic Autoimmune Diseases
title_full Complement as a Therapeutic Target in Systemic Autoimmune Diseases
title_fullStr Complement as a Therapeutic Target in Systemic Autoimmune Diseases
title_full_unstemmed Complement as a Therapeutic Target in Systemic Autoimmune Diseases
title_sort Complement as a Therapeutic Target in Systemic Autoimmune Diseases
dc.creator.none.fl_str_mv Galindo Izquierdo, María
Pablos Álvarez, José Luis
author Galindo Izquierdo, María
author_facet Galindo Izquierdo, María
Pablos Álvarez, José Luis
author_role author
author2 Pablos Álvarez, José Luis
author2_role author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv complement system
pathogenesis
therapeutic blockade
rheumatic autoimmune diseases
Reumatología
3205.09 Reumatología
topic complement system
pathogenesis
therapeutic blockade
rheumatic autoimmune diseases
Reumatología
3205.09 Reumatología
description The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune processes in which complement plays a pathogenic role and its potential relevance as a therapeutic target.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-13
2021
2021-01-13
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/7131
url https://hdl.handle.net/20.500.14352/7131
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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