Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles

This work aimed at studying the effect of molecular weight (MW) and deacetylation degree (DD) of chitosan on the quercetin bioaccessibility encapsulated in alginate/chitosan-coated zein nanoparticles (alg/chiZN). The chitosan coating layer produced nanoparticulate systems with good stability paramet...

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Detalles Bibliográficos
Autores: Carrasco-Sandoval, Jonathan, Aranda, Mario, Henríquez-Aedo, Karem, Fernández, Marcos, López-Rubio, Amparo, Fabra, María José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/309702
Acceso en línea:http://hdl.handle.net/10261/309702
https://api.elsevier.com/content/abstract/scopus_id/85159183704
Access Level:acceso abierto
Palabra clave:Chitosan
Deacetylation degree
Molecular weight
Nanoparticles
Quercetin
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spelling Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticlesCarrasco-Sandoval, JonathanAranda, MarioHenríquez-Aedo, KaremFernández, MarcosLópez-Rubio, AmparoFabra, María JoséChitosanDeacetylation degreeMolecular weightNanoparticlesQuercetinThis work aimed at studying the effect of molecular weight (MW) and deacetylation degree (DD) of chitosan on the quercetin bioaccessibility encapsulated in alginate/chitosan-coated zein nanoparticles (alg/chiZN). The chitosan coating layer produced nanoparticulate systems with good stability parameters, high encapsulation efficiency (EE) and a higher bioaccessibilty of quercetin after in-vitro digestion. By increasing the DD of chitosan, the ζ-potential of the colloidal system significantly increased (≥27.1 mV), while low and very low MW chitosans generated systems with smaller particle sizes (≤ 277.8 nm) and polydispersity index [PDI (0.189)]. The best results, in terms of EE (≥84.44) and bioaccessibility (≥76.70), were obtained when the systems were prepared with low MW chitosan and high DD. Thus, the alg/chiZN nanocapsules may be a promising delivery system for improving the quercetin bioaccessibility or other compounds with a similar chemical nature, especially when higher DD and lower MWs are used.This work was financially supported by National Fund for Scientific & Technological Development (FONDECYT), projects No 1211803 and No 1201658, project FOVI210081, and Fund for Scientific and Technological Equipment (FONDEQUIP) project No. 130209.Peer reviewedElsevierFondo Nacional de Desarrollo Científico y Tecnológico (Chile)#NODATA##NODATA##NODATA##NODATA##NODATA##NODATA#Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/309702https://api.elsevier.com/content/abstract/scopus_id/85159183704reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInternational journal of biological macromoleculeshttps://dx.doi.org/10.1016/j.ijbiomac.2023.124876Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3097022026-05-22T06:33:51Z
dc.title.none.fl_str_mv Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
title Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
spellingShingle Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
Carrasco-Sandoval, Jonathan
Chitosan
Deacetylation degree
Molecular weight
Nanoparticles
Quercetin
title_short Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
title_full Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
title_fullStr Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
title_full_unstemmed Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
title_sort Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
dc.creator.none.fl_str_mv Carrasco-Sandoval, Jonathan
Aranda, Mario
Henríquez-Aedo, Karem
Fernández, Marcos
López-Rubio, Amparo
Fabra, María José
author Carrasco-Sandoval, Jonathan
author_facet Carrasco-Sandoval, Jonathan
Aranda, Mario
Henríquez-Aedo, Karem
Fernández, Marcos
López-Rubio, Amparo
Fabra, María José
author_role author
author2 Aranda, Mario
Henríquez-Aedo, Karem
Fernández, Marcos
López-Rubio, Amparo
Fabra, María José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Fondo Nacional de Desarrollo Científico y Tecnológico (Chile)
#NODATA#
#NODATA#
#NODATA#
#NODATA#
#NODATA#
#NODATA#
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Chitosan
Deacetylation degree
Molecular weight
Nanoparticles
Quercetin
topic Chitosan
Deacetylation degree
Molecular weight
Nanoparticles
Quercetin
description This work aimed at studying the effect of molecular weight (MW) and deacetylation degree (DD) of chitosan on the quercetin bioaccessibility encapsulated in alginate/chitosan-coated zein nanoparticles (alg/chiZN). The chitosan coating layer produced nanoparticulate systems with good stability parameters, high encapsulation efficiency (EE) and a higher bioaccessibilty of quercetin after in-vitro digestion. By increasing the DD of chitosan, the ζ-potential of the colloidal system significantly increased (≥27.1 mV), while low and very low MW chitosans generated systems with smaller particle sizes (≤ 277.8 nm) and polydispersity index [PDI (0.189)]. The best results, in terms of EE (≥84.44) and bioaccessibility (≥76.70), were obtained when the systems were prepared with low MW chitosan and high DD. Thus, the alg/chiZN nanocapsules may be a promising delivery system for improving the quercetin bioaccessibility or other compounds with a similar chemical nature, especially when higher DD and lower MWs are used.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/309702
https://api.elsevier.com/content/abstract/scopus_id/85159183704
url http://hdl.handle.net/10261/309702
https://api.elsevier.com/content/abstract/scopus_id/85159183704
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International journal of biological macromolecules
https://dx.doi.org/10.1016/j.ijbiomac.2023.124876
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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