Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles
This work aimed at studying the effect of molecular weight (MW) and deacetylation degree (DD) of chitosan on the quercetin bioaccessibility encapsulated in alginate/chitosan-coated zein nanoparticles (alg/chiZN). The chitosan coating layer produced nanoparticulate systems with good stability paramet...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/309702 |
| Acceso en línea: | http://hdl.handle.net/10261/309702 https://api.elsevier.com/content/abstract/scopus_id/85159183704 |
| Access Level: | acceso abierto |
| Palabra clave: | Chitosan Deacetylation degree Molecular weight Nanoparticles Quercetin |
| Sumario: | This work aimed at studying the effect of molecular weight (MW) and deacetylation degree (DD) of chitosan on the quercetin bioaccessibility encapsulated in alginate/chitosan-coated zein nanoparticles (alg/chiZN). The chitosan coating layer produced nanoparticulate systems with good stability parameters, high encapsulation efficiency (EE) and a higher bioaccessibilty of quercetin after in-vitro digestion. By increasing the DD of chitosan, the ζ-potential of the colloidal system significantly increased (≥27.1 mV), while low and very low MW chitosans generated systems with smaller particle sizes (≤ 277.8 nm) and polydispersity index [PDI (0.189)]. The best results, in terms of EE (≥84.44) and bioaccessibility (≥76.70), were obtained when the systems were prepared with low MW chitosan and high DD. Thus, the alg/chiZN nanocapsules may be a promising delivery system for improving the quercetin bioaccessibility or other compounds with a similar chemical nature, especially when higher DD and lower MWs are used. |
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