Music compensates for altered gene expression in age-related cognitive disorders

Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathway...

Full description

Bibliographic Details
Authors: Gómez Carballa, Alberto, Navarro, L., Pardo Seco, Jacobo José, Bello, X., Pischedda, Sara, Viz Lasheras, Sandra, Camino-Mera, A., Currás, M.J., Ferreirós, I., Mallah ., Narmeen, Rey-Vázquez, S., Redondo, L., Dacosta-Urbieta, A., Caamaño-Viña, F., Rivero Calle, Irene, Rodriguez-Tenreiro, C., Martinón Torres, Federico, Salas Ellacuriaga, Antonio
Format: article
Publication Date:2023
Country:España
Institution:Servizo Galego de Saúde (SERGAS)
Repository:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21765
Online Access:https://portalcientifico.sergas.gal//documentos/657f1aca3ea324404509bfac
http://hdl.handle.net/20.500.11940/21765
Access Level:Open access
Keyword:Humans
Music
Cohort Studies
Cognition Disorders
Cognitive Dysfunction
Alzheimer Disease
Gene Expression
AS Santiago
IDIS
CHUS
id ES_aaf8fca409ac59b83e6478c3e792ecd0
oai_identifier_str oai:runa.sergas.gal:20.500.11940/21765
network_acronym_str ES
network_name_str España
repository_id_str
spelling Music compensates for altered gene expression in age-related cognitive disordersGómez Carballa, AlbertoNavarro, L.Pardo Seco, Jacobo JoséBello, X.Pischedda, SaraViz Lasheras, SandraCamino-Mera, A.Currás, M.J.Ferreirós, I.Mallah ., NarmeenRey-Vázquez, S.Redondo, L.Dacosta-Urbieta, A.Caamaño-Viña, F.Rivero Calle, IreneRodriguez-Tenreiro, C.Martinón Torres, FedericoSalas Ellacuriaga, AntonioHumansMusicCohort StudiesCognition DisordersCognitive DysfunctionAlzheimer DiseaseGene ExpressionAS SantiagoIDISAS SantiagoIDISAS SantiagoIDISAS SantiagoIDISAS SantiagoIDISAS SantiagoCHUSAS SantiagoCHUSAS SantiagoIDISExtensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer's disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than in controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders.This study received support from GAIN: Grupos con Potencial de Crecimiento [IN607B 2020/08, (A.S.)] and Grupos de Referencia Competitiva [IN607A2023/02 (A.S.), IIN607A2021/05 (F.M-T)].2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/657f1aca3ea324404509bfachttp://hdl.handle.net/20.500.11940/21765reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/217652026-06-12T08:40:47Z
dc.title.none.fl_str_mv Music compensates for altered gene expression in age-related cognitive disorders
title Music compensates for altered gene expression in age-related cognitive disorders
spellingShingle Music compensates for altered gene expression in age-related cognitive disorders
Gómez Carballa, Alberto
Humans
Music
Cohort Studies
Cognition Disorders
Cognitive Dysfunction
Alzheimer Disease
Gene Expression
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
CHUS
AS Santiago
CHUS
AS Santiago
IDIS
title_short Music compensates for altered gene expression in age-related cognitive disorders
title_full Music compensates for altered gene expression in age-related cognitive disorders
title_fullStr Music compensates for altered gene expression in age-related cognitive disorders
title_full_unstemmed Music compensates for altered gene expression in age-related cognitive disorders
title_sort Music compensates for altered gene expression in age-related cognitive disorders
dc.creator.none.fl_str_mv Gómez Carballa, Alberto
Navarro, L.
Pardo Seco, Jacobo José
Bello, X.
Pischedda, Sara
Viz Lasheras, Sandra
Camino-Mera, A.
Currás, M.J.
Ferreirós, I.
Mallah ., Narmeen
Rey-Vázquez, S.
Redondo, L.
Dacosta-Urbieta, A.
Caamaño-Viña, F.
Rivero Calle, Irene
Rodriguez-Tenreiro, C.
Martinón Torres, Federico
Salas Ellacuriaga, Antonio
author Gómez Carballa, Alberto
author_facet Gómez Carballa, Alberto
Navarro, L.
Pardo Seco, Jacobo José
Bello, X.
Pischedda, Sara
Viz Lasheras, Sandra
Camino-Mera, A.
Currás, M.J.
Ferreirós, I.
Mallah ., Narmeen
Rey-Vázquez, S.
Redondo, L.
Dacosta-Urbieta, A.
Caamaño-Viña, F.
Rivero Calle, Irene
Rodriguez-Tenreiro, C.
Martinón Torres, Federico
Salas Ellacuriaga, Antonio
author_role author
author2 Navarro, L.
Pardo Seco, Jacobo José
Bello, X.
Pischedda, Sara
Viz Lasheras, Sandra
Camino-Mera, A.
Currás, M.J.
Ferreirós, I.
Mallah ., Narmeen
Rey-Vázquez, S.
Redondo, L.
Dacosta-Urbieta, A.
Caamaño-Viña, F.
Rivero Calle, Irene
Rodriguez-Tenreiro, C.
Martinón Torres, Federico
Salas Ellacuriaga, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Humans
Music
Cohort Studies
Cognition Disorders
Cognitive Dysfunction
Alzheimer Disease
Gene Expression
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
CHUS
AS Santiago
CHUS
AS Santiago
IDIS
topic Humans
Music
Cohort Studies
Cognition Disorders
Cognitive Dysfunction
Alzheimer Disease
Gene Expression
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
IDIS
AS Santiago
CHUS
AS Santiago
CHUS
AS Santiago
IDIS
description Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer's disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than in controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/657f1aca3ea324404509bfac
http://hdl.handle.net/20.500.11940/21765
url https://portalcientifico.sergas.gal//documentos/657f1aca3ea324404509bfac
http://hdl.handle.net/20.500.11940/21765
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869416227741368320
score 15,812429

Similar Items