Music compensates for altered gene expression in age-related cognitive disorders

Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathway...

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Detalles Bibliográficos
Autores: Gómez Carballa, Alberto, Navarro, L., Pardo Seco, Jacobo José, Bello, X., Pischedda, Sara, Viz Lasheras, Sandra, Camino-Mera, A., Currás, M.J., Ferreirós, I., Mallah ., Narmeen, Rey-Vázquez, S., Redondo, L., Dacosta-Urbieta, A., Caamaño-Viña, F., Rivero Calle, Irene, Rodriguez-Tenreiro, C., Martinón Torres, Federico, Salas Ellacuriaga, Antonio
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21765
Acceso en línea:https://portalcientifico.sergas.gal//documentos/657f1aca3ea324404509bfac
http://hdl.handle.net/20.500.11940/21765
Access Level:acceso abierto
Palabra clave:Humans
Music
Cohort Studies
Cognition Disorders
Cognitive Dysfunction
Alzheimer Disease
Gene Expression
AS Santiago
IDIS
CHUS
Descripción
Sumario:Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer's disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than in controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders.

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