Association of periodontitis with cognitive decline and its progression: Contribution of blood-based biomarkers of Alzheimer's disease to this relationship

Aim: To assess whether periodontitis is associated with cognitive decline and its progression as well as with certain blood-based markers of Alzheimer's disease. Materials and Methods: Data from a 2-year follow-up prospective cohort study (n = 101) was analysed. Participants with a previous his...

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Detalles Bibliográficos
Autores: Carballo, Á., López Dequidt, Iria Alejandra, Custodia Malvido, Antía, Botelho, J., Aramburu Nuñez, Marta, Machado, V., Pias Peleteiro, Juan Manuel, Ouro Villasante, Alberto, Romaus Sanjurjo, Daniel, Vázquez-Vázquez, L., Jiménez Martín, Isabel, Aguiar Fernández, Pablo, Rodríguez Yáñez, Manuel, Aldrey Vázquez, José Manuel, Blanco, J., Castillo Sánchez, José, Sobrino Moreiras, Tomas, Leira Feijoo, Yago
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21122
Acceso en línea:https://portalcientifico.sergas.gal//documentos/64ec7b67e13d1f2d6d3b7024
http://hdl.handle.net/20.500.11940/21122
Access Level:acceso abierto
Palabra clave:Aged
Humans
Alzheimer Disease
Amyloid beta-Peptides
Prospective Studies
tau Proteins
Cognitive Dysfunction
Biomarkers
Hypertension
Periodontitis
Disease Progression
Peptide Fragments
AS Ferrol
IDIS
AS Santiago
HP Barbanza
CHUS
Descripción
Sumario:Aim: To assess whether periodontitis is associated with cognitive decline and its progression as well as with certain blood-based markers of Alzheimer's disease. Materials and Methods: Data from a 2-year follow-up prospective cohort study (n = 101) was analysed. Participants with a previous history of hypertension and aged ?60 years were included in the analysis. All of them received a full-mouth periodontal examination and cognitive function assessments (Addenbrooke's Cognitive Examination (ACE) and Mini-Mental State Examination [MMSE]). Plasma levels of amyloid beta (A?)1-40, A?1-42, phosphorylated and total Tau (p-Tau and t-Tau) were determined at baseline, 12 and 24 months. Results: Periodontitis was associated with poor cognitive performance (MMSE: ? = ?1.5 [0.6]) and progression of cognitive impairment (hazard ratio [HR] = 1.8; 95% confidence interval: 1.0-3.1). Subjects with periodontitis showed greater baseline levels of p-Tau (1.6 [0.7] vs. 1.2 [0.2] pg/mL, p <.001) and A?1-40 (242.1 [77.3] vs. 208.2 [73.8] pg/mL, p =.036) compared with those without periodontitis. Concentrations of the latter protein also increased over time only in the periodontitis group (p =.005). Conclusions: Periodontitis is associated with cognitive decline and its progression in elderly patients with a previous history of hypertension. Overexpression of p-Tau and A?1-40 may play a role in this association.

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