Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Delaby, C; Teunissen, CE; Blennow, K; Alcolea, D; Arisi, I; Amar, EB; Beaume, A; Bedel, A; Bellomo, G; Bigot-Corbel, E; Bjerke, M; Blanc-Quintin, MC; Boada, M; Bousiges, O; Chapman, MD; DeMarco, ML; D'Onofrio, M; Dumurgier, J; Dufour-Rainfray, D; Engelborghs, S; Esselmann, H; Fogli, A; Gabelle, A; Galloni, E; Gondolf, C; Grandhomme, F; Grau-Rivera, O; Hart, M; Ikeuchi, T; Jeromin, A; Kasuga, K; Keshavan, A; Khalil, M; Kortvelyessy, P; Kulczynska-Przybik, A; Laplanche, JL; Lewczuk, P; Li, QX; Lleo, A; Malaplate, C; Marquie, M; Masters, CL; Mroczko, B; Nogueira, L; Orellana, A; Otto, M; Oudart, JB; Paquet, C; Paoletti, FP; Parnetti, L; Perret-Liaudet, A; Peoc'h, K; Poesen, K; Puig-Pijoan, A; Quadrio, I; Quillard-Muraine, M; Rucheton, B; Schraen, S; Schott, JM; Shaw, LM; Suarez-Calvet, M; Tsolaki, M; Tumani, H; Udeh-Momoh, CT; Vaudran, L; Verbeek, MM; Verde, F; Vermunt, L; Vogelgsang, J; Wiltfang, J; Zetterberg, H; Lehmann, S

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of resultsmay differ, which can lead tomisunderstandings and r...

Descripción completa

Detalles Bibliográficos
Autores:	Delaby, C, Teunissen, CE, Blennow, K, Alcolea, D, Arisi, I, Amar, EB, Beaume, A, Bedel, A, Bellomo, G, Bigot-Corbel, E, Bjerke, M, Blanc-Quintin, MC, Boada, M, Bousiges, O, Chapman, MD, DeMarco, ML, D'Onofrio, M, Dumurgier, J, Dufour-Rainfray, D, Engelborghs, S, Esselmann, H, Fogli, A, Gabelle, A, Galloni, E, Gondolf, C, Grandhomme, F, Grau-Rivera, O, Hart, M, Ikeuchi, T, Jeromin, A, Kasuga, K, Keshavan, A, Khalil, M, Kortvelyessy, P, Kulczynska-Przybik, A, Laplanche, JL, Lewczuk, P, Li, QX, Lleo, A, Malaplate, C, Marquie, M, Masters, CL, Mroczko, B, Nogueira, L, Orellana, A, Otto, M, Oudart, JB, Paquet, C, Paoletti, FP, Parnetti, L, Perret-Liaudet, A, Peoc'h, K, Poesen, K, Puig-Pijoan, A, Quadrio, I, Quillard-Muraine, M, Rucheton, B, Schraen, S, Schott, JM, Shaw, LM, Suarez-Calvet, M, Tsolaki, M, Tumani, H, Udeh-Momoh, CT, Vaudran, L, Verbeek, MM, Verde, F, Vermunt, L, Vogelgsang, J, Wiltfang, J, Zetterberg, H, Lehmann, S
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p5850
Acceso en línea:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5850 https://researchportal.vub.be/en/publications/clinical-reporting-following-the-quantification-of-cerebrospinal-
Access Level:	acceso abierto
Palabra clave:	Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization

id	ES_a8fd1b7795d76a20cc2cfd1b2e59f5d5
oai_identifier_str	oai:iibsantpau.fundanetsuite.com:p5850
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overviewDelaby, CTeunissen, CEBlennow, KAlcolea, DArisi, IAmar, EBBeaume, ABedel, ABellomo, GBigot-Corbel, EBjerke, MBlanc-Quintin, MCBoada, MBousiges, OChapman, MDDeMarco, MLD'Onofrio, MDumurgier, JDufour-Rainfray, DEngelborghs, SEsselmann, HFogli, AGabelle, AGalloni, EGondolf, CGrandhomme, FGrau-Rivera, OHart, MIkeuchi, TJeromin, AKasuga, KKeshavan, AKhalil, MKortvelyessy, PKulczynska-Przybik, ALaplanche, JLLewczuk, PLi, QXLleo, AMalaplate, CMarquie, MMasters, CLMroczko, BNogueira, LOrellana, AOtto, MOudart, JBPaquet, CPaoletti, FPParnetti, LPerret-Liaudet, APeoc'h, KPoesen, KPuig-Pijoan, AQuadrio, IQuillard-Muraine, MRucheton, BSchraen, SSchott, JMShaw, LMSuarez-Calvet, MTsolaki, MTumani, HUdeh-Momoh, CTVaudran, LVerbeek, MMVerde, FVermunt, LVogelgsang, JWiltfang, JZetterberg, HLehmann, SAlzheimer's diseasecerebrospinal fluid biomarkersclinical reportconsensus approachharmonizationIntroduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of resultsmay differ, which can lead tomisunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.WILEY2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5850https://researchportal.vub.be/en/publications/clinical-reporting-following-the-quantification-of-cerebrospinal-ALZHEIMERS & DEMENTIAISSN: 15525260ISSNe: 15525279reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p58502026-06-14T12:41:47Z
dc.title.none.fl_str_mv	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
title	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
spellingShingle	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview Delaby, C Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization
title_short	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
title_full	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
title_fullStr	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
title_full_unstemmed	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
title_sort	Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
dc.creator.none.fl_str_mv	Delaby, C Teunissen, CE Blennow, K Alcolea, D Arisi, I Amar, EB Beaume, A Bedel, A Bellomo, G Bigot-Corbel, E Bjerke, M Blanc-Quintin, MC Boada, M Bousiges, O Chapman, MD DeMarco, ML D'Onofrio, M Dumurgier, J Dufour-Rainfray, D Engelborghs, S Esselmann, H Fogli, A Gabelle, A Galloni, E Gondolf, C Grandhomme, F Grau-Rivera, O Hart, M Ikeuchi, T Jeromin, A Kasuga, K Keshavan, A Khalil, M Kortvelyessy, P Kulczynska-Przybik, A Laplanche, JL Lewczuk, P Li, QX Lleo, A Malaplate, C Marquie, M Masters, CL Mroczko, B Nogueira, L Orellana, A Otto, M Oudart, JB Paquet, C Paoletti, FP Parnetti, L Perret-Liaudet, A Peoc'h, K Poesen, K Puig-Pijoan, A Quadrio, I Quillard-Muraine, M Rucheton, B Schraen, S Schott, JM Shaw, LM Suarez-Calvet, M Tsolaki, M Tumani, H Udeh-Momoh, CT Vaudran, L Verbeek, MM Verde, F Vermunt, L Vogelgsang, J Wiltfang, J Zetterberg, H Lehmann, S
author	Delaby, C
author_facet	Delaby, C Teunissen, CE Blennow, K Alcolea, D Arisi, I Amar, EB Beaume, A Bedel, A Bellomo, G Bigot-Corbel, E Bjerke, M Blanc-Quintin, MC Boada, M Bousiges, O Chapman, MD DeMarco, ML D'Onofrio, M Dumurgier, J Dufour-Rainfray, D Engelborghs, S Esselmann, H Fogli, A Gabelle, A Galloni, E Gondolf, C Grandhomme, F Grau-Rivera, O Hart, M Ikeuchi, T Jeromin, A Kasuga, K Keshavan, A Khalil, M Kortvelyessy, P Kulczynska-Przybik, A Laplanche, JL Lewczuk, P Li, QX Lleo, A Malaplate, C Marquie, M Masters, CL Mroczko, B Nogueira, L Orellana, A Otto, M Oudart, JB Paquet, C Paoletti, FP Parnetti, L Perret-Liaudet, A Peoc'h, K Poesen, K Puig-Pijoan, A Quadrio, I Quillard-Muraine, M Rucheton, B Schraen, S Schott, JM Shaw, LM Suarez-Calvet, M Tsolaki, M Tumani, H Udeh-Momoh, CT Vaudran, L Verbeek, MM Verde, F Vermunt, L Vogelgsang, J Wiltfang, J Zetterberg, H Lehmann, S
author_role	author
author2	Teunissen, CE Blennow, K Alcolea, D Arisi, I Amar, EB Beaume, A Bedel, A Bellomo, G Bigot-Corbel, E Bjerke, M Blanc-Quintin, MC Boada, M Bousiges, O Chapman, MD DeMarco, ML D'Onofrio, M Dumurgier, J Dufour-Rainfray, D Engelborghs, S Esselmann, H Fogli, A Gabelle, A Galloni, E Gondolf, C Grandhomme, F Grau-Rivera, O Hart, M Ikeuchi, T Jeromin, A Kasuga, K Keshavan, A Khalil, M Kortvelyessy, P Kulczynska-Przybik, A Laplanche, JL Lewczuk, P Li, QX Lleo, A Malaplate, C Marquie, M Masters, CL Mroczko, B Nogueira, L Orellana, A Otto, M Oudart, JB Paquet, C Paoletti, FP Parnetti, L Perret-Liaudet, A Peoc'h, K Poesen, K Puig-Pijoan, A Quadrio, I Quillard-Muraine, M Rucheton, B Schraen, S Schott, JM Shaw, LM Suarez-Calvet, M Tsolaki, M Tumani, H Udeh-Momoh, CT Vaudran, L Verbeek, MM Verde, F Vermunt, L Vogelgsang, J Wiltfang, J Zetterberg, H Lehmann, S
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization
topic	Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization
description	Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of resultsmay differ, which can lead tomisunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.
publishDate	2022
dc.date.none.fl_str_mv	2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5850 https://researchportal.vub.be/en/publications/clinical-reporting-following-the-quantification-of-cerebrospinal-
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5850 https://researchportal.vub.be/en/publications/clinical-reporting-following-the-quantification-of-cerebrospinal-
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	WILEY
publisher.none.fl_str_mv	WILEY
dc.source.none.fl_str_mv	ALZHEIMERS & DEMENTIA ISSN: 15525260 ISSNe: 15525279 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869415963321958400
score	15.812455

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Similares en LA Referencia