Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview

INTRODUCTIONNeurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the glob...

Descripción completa

Detalles Bibliográficos
Autores: Delaby, C, Ladang, A, Martinez-Yriarte, J, Zecca, C, Logroscino, G, Koertvelyessy, P, Tumani, H, Parchi, P, Quadrio, I, Hart, M, Olsen, DA, Alcolea, D, Blennow, K, Fortea, J, Lleo, A, Algeciras-Schimnich, A, Ayrignac, X, Bedel, A, Santos, GAA, Borelli, W, Bouaziz-Amar, E, Baldeiras, I, Bigot-Corbel, E, Bjerke, M, Perez, MC, Casoli, T, Chabrashvili, T, Chapman, MD, Cusato, J, Dursun, E, Fourier, A, Galimberti, D, Gezen-Ak, D, Gordon, BA, Gouju, J, Florez, SD, Sanchez, JH, Herwerth, M, Imperiale, D, Kaczorowski, F, Kasuga, K, Keshavan, A, Khalil, M, Kuhle, J, Leithner, C, Lewczuk, P, Letournel, F, Tsolaki, M, Giuffre, GM, Blanc, MC, Mroczko, B, Rodriguez, JEM, Musso, G, Kulczynska-Przybik, A, Nogueira, L, Paquet, C, Baiardi, S, Gaetani, L, Parnetti, L, Garay, RP, Poesen, K, Quillard-Muraine, M, Borja, ER, Schraen, S, Terracciano, D, Bachhuber, F, Halbgebauer, S, Tzartos, S, Tzartos, J, Unterwalder, N, Vermunt, L, Wellington, CL, Zetterberg, H, Teunissen, C, Lehmann, S
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19962
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19962
Access Level:acceso abierto
Palabra clave:biomarkers
blood
cerebrospinal fluid
clinical report
consensus approach
harmonization
neurofilaments
Descripción
Sumario:INTRODUCTIONNeurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts.METHODSWe established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.RESULTSAmong the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%).DISCUSSIONHarmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice.Highlights Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice. Tailored sheets for each neurological application. Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.

Similares en LA Referencia