Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease

The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questi...

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Detalhes bibliográficos
Autores: Delaby, Constance|||0000-0002-8606-6814, Teunissen, Charlotte E.|||0000-0002-4061-0837, Blennow, Kaj|||0000-0002-1890-4193, Alcolea, Daniel|||0000-0002-3819-3245, Arisi, Ivan, Amar, Elodie Bouaziz, Beaume, Anne, Bedel, Aurelie, Bellomo, Giovanni|||0000-0003-0456-5650, Bigot-Corbel, Edith, Bjerke, Maria, Blanc-Quintin, Marie-Céline, Boada, Mercè|||0000-0003-2617-3009, Bousiges, Olivier|||0000-0001-6786-3191, Chapman, Miles D., DeMarco, Mari L., D'Onofrio, Mara, Dumurgier, Julien, Dufour-Rainfray, Diane, Engelborghs, Sebastiaan|||0000-0003-0304-9785, Esselmann, Hermann, Fogli, Anne, Gabelle, Audrey, Galloni, Elisabetta, Gondolf, Clémentine, Grandhomme, Frédérique, Grau-Rivera, Oriol|||0000-0002-4730-5341, Hart, Melanie, Ikeuchi, Takeshi|||0000-0001-8828-8085, Jeromin, Andreas, Kasuga, Kensaku, Keshavan, Ashvini, Khalil, Michael|||0000-0002-5350-3328, Körtvelyessy, Peter, Kulczynska-Przybik, Agnieszka, Laplanche, Jean-Louis, Lewczuk, Piotr|||0000-0002-8101-6535, Li, Qiao-Xin, Lleó, Alberto|||0000-0002-2568-5478, Malaplate, Catherine, Marquié, Marta|||0000-0002-0660-0950, Masters, Colin L., Mroczko, Barbara, Nogueira, Léonor, Orellana del Río, Adelina|||0000-0002-0204-1944, Otto, Markus, Oudart, Jean-Baptiste, Paquet, Claire|||0000-0002-2273-7316, Paoletti, Federico Paolini, Parnetti, Lucilla|||0000-0001-5722-3967, Perret-Liaudet, Armand, Peoc'h, Katell, Poesen, Koen, Puig-Pijoan, Albert|||0000-0002-9848-3711, Quadrio, Isabelle, Quillard-Muraine, Muriel, Rucheton, Benoit, Schraen, Susanna, Schott, Jonathan M.|||0000-0003-2059-024X, Shaw, Leslie M., Suárez-Calvet, Marc|||0000-0002-2993-569X, Tsolaki, Magda|||0000-0002-2072-8010, Tumani, Hayrettin|||0000-0002-1647-6201, Udeh-Momoh, Chinedu|||0000-0002-7357-4692, Vaudran, Lucie, Verbeek, Marcel M., Verde, Federico, Vermunt, Lisa, Vogelgsang, Jonathan|||0000-0001-9326-8193, Wiltfang, Jens, Zetterberg, Henrik|||0000-0003-3930-4354, Lehmann, Sylvain|||0000-0001-6117-562X
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:280541
Acesso em linha:https://ddd.uab.cat/record/280541
https://dx.doi.org/urn:doi:10.1002/alz.12545
Access Level:acceso abierto
Palavra-chave:Alzheimer's disease
Cerebrospinal fluid biomarkers
Clinical report
Consensus approach
Harmonization
Descrição
Resumo:The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.

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