Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene

Montero, P. (Pilar)|||/items/16d0acec-277d-4dba-9c72-cc02731289a5; Flandes-Iparraguirre, M. (María)|||/items/a6e2b5bc-d2e2-4e55-a013-a472f9083dc1; Kuebler, B. (Brend)|||/items/093707f5-3c5b-48fa-b198-1896cd6206ab; Arán, B. (Begoña)|||/items/cef67dd1-6904-42bb-b065-621b03516c2b; Larequi-García, E. (Eduardo)|||/items/c82f1e42-2768-4025-bddc-ad659209577c; Anaut, I. (Ilazki)|||/items/71e222fc-9392-4de1-889c-1fc0aa89b57c; Coppiello, G. (Giulia)|||/items/d1d63554-537e-458e-8f86-02ae9264fe14; Veiga, A. (Anna)|||/items/f0b660bd-aaff-4fc0-9688-dc5e128d2ee9; Basurte-Elorz, M.T. (María Teresa)|||/items/ea05810c-ca40-4d1a-a81f-ccec06313130; García-de-Yébenes-Castro, M. (Manuel)|||/items/1d967062-cbca-4f77-b0f0-fabea77e39db; Gavira-Gómez, J.J. (Juan José)|||/items/a253ead5-4ef7-4b80-9aab-43b47605270e; Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1; Iglesias-García, O. (Olalla)|||/items/93424e57-6115-4ea0-bcea-436fa10ec58d; Mazo-Vega, M.M. (Manuel María)|||/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e; Aranguren-López, X. (Xabier)|||/items/217519c3-f392-48cb-b4c9-87d4e2fd0570

Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene

Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linked to cardiac toxicity and progression toward heart failure. A...

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Detalles Bibliográficos
Autores:	Montero, P. (Pilar)\|\|\|/items/16d0acec-277d-4dba-9c72-cc02731289a5, Flandes-Iparraguirre, M. (María)\|\|\|/items/a6e2b5bc-d2e2-4e55-a013-a472f9083dc1, Kuebler, B. (Brend)\|\|\|/items/093707f5-3c5b-48fa-b198-1896cd6206ab, Arán, B. (Begoña)\|\|\|/items/cef67dd1-6904-42bb-b065-621b03516c2b, Larequi-García, E. (Eduardo)\|\|\|/items/c82f1e42-2768-4025-bddc-ad659209577c, Anaut, I. (Ilazki)\|\|\|/items/71e222fc-9392-4de1-889c-1fc0aa89b57c, Coppiello, G. (Giulia)\|\|\|/items/d1d63554-537e-458e-8f86-02ae9264fe14, Veiga, A. (Anna)\|\|\|/items/f0b660bd-aaff-4fc0-9688-dc5e128d2ee9, Basurte-Elorz, M.T. (María Teresa)\|\|\|/items/ea05810c-ca40-4d1a-a81f-ccec06313130, García-de-Yébenes-Castro, M. (Manuel)\|\|\|/items/1d967062-cbca-4f77-b0f0-fabea77e39db, Gavira-Gómez, J.J. (Juan José)\|\|\|/items/a253ead5-4ef7-4b80-9aab-43b47605270e, Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1, Iglesias-García, O. (Olalla)\|\|\|/items/93424e57-6115-4ea0-bcea-436fa10ec58d, Mazo-Vega, M.M. (Manuel María)\|\|\|/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e, Aranguren-López, X. (Xabier)\|\|\|/items/217519c3-f392-48cb-b4c9-87d4e2fd0570
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/67334
Acceso en línea:	https://hdl.handle.net/10171/67334
Access Level:	acceso abierto
Palabra clave:	Transthyretin Amyloid cardiomyopathy Liver cells Pluripotent stem cell (iPSC)

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spelling	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR geneMontero, P. (Pilar)\|\|\|/items/16d0acec-277d-4dba-9c72-cc02731289a5Flandes-Iparraguirre, M. (María)\|\|\|/items/a6e2b5bc-d2e2-4e55-a013-a472f9083dc1Kuebler, B. (Brend)\|\|\|/items/093707f5-3c5b-48fa-b198-1896cd6206abArán, B. (Begoña)\|\|\|/items/cef67dd1-6904-42bb-b065-621b03516c2bLarequi-García, E. (Eduardo)\|\|\|/items/c82f1e42-2768-4025-bddc-ad659209577cAnaut, I. (Ilazki)\|\|\|/items/71e222fc-9392-4de1-889c-1fc0aa89b57cCoppiello, G. (Giulia)\|\|\|/items/d1d63554-537e-458e-8f86-02ae9264fe14Veiga, A. (Anna)\|\|\|/items/f0b660bd-aaff-4fc0-9688-dc5e128d2ee9Basurte-Elorz, M.T. (María Teresa)\|\|\|/items/ea05810c-ca40-4d1a-a81f-ccec06313130García-de-Yébenes-Castro, M. (Manuel)\|\|\|/items/1d967062-cbca-4f77-b0f0-fabea77e39dbGavira-Gómez, J.J. (Juan José)\|\|\|/items/a253ead5-4ef7-4b80-9aab-43b47605270eProsper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1Iglesias-García, O. (Olalla)\|\|\|/items/93424e57-6115-4ea0-bcea-436fa10ec58dMazo-Vega, M.M. (Manuel María)\|\|\|/items/c871e8d9-ee5d-487b-97ef-7302feb8a02eAranguren-López, X. (Xabier)\|\|\|/items/217519c3-f392-48cb-b4c9-87d4e2fd0570TransthyretinAmyloid cardiomyopathyLiver cellsPluripotent stem cell (iPSC)Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linked to cardiac toxicity and progression toward heart failure. A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) from a patient suffering familial transthyretin amyloid cardiomyopathy carrying a c.128G>A (p.Ser43Asn) mutation in the TTR gene. This iPSC line offers a useful resource to study the disease pathophysiology and a cell-based model for therapeutic discovery.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20232023-09-2720232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/67334reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/673342026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
title	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
spellingShingle	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene Montero, P. (Pilar)\|\|\|/items/16d0acec-277d-4dba-9c72-cc02731289a5 Transthyretin Amyloid cardiomyopathy Liver cells Pluripotent stem cell (iPSC)
title_short	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
title_full	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
title_fullStr	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
title_full_unstemmed	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
title_sort	Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene
dc.creator.none.fl_str_mv	Montero, P. (Pilar)\|\|\|/items/16d0acec-277d-4dba-9c72-cc02731289a5 Flandes-Iparraguirre, M. (María)\|\|\|/items/a6e2b5bc-d2e2-4e55-a013-a472f9083dc1 Kuebler, B. (Brend)\|\|\|/items/093707f5-3c5b-48fa-b198-1896cd6206ab Arán, B. (Begoña)\|\|\|/items/cef67dd1-6904-42bb-b065-621b03516c2b Larequi-García, E. (Eduardo)\|\|\|/items/c82f1e42-2768-4025-bddc-ad659209577c Anaut, I. (Ilazki)\|\|\|/items/71e222fc-9392-4de1-889c-1fc0aa89b57c Coppiello, G. (Giulia)\|\|\|/items/d1d63554-537e-458e-8f86-02ae9264fe14 Veiga, A. (Anna)\|\|\|/items/f0b660bd-aaff-4fc0-9688-dc5e128d2ee9 Basurte-Elorz, M.T. (María Teresa)\|\|\|/items/ea05810c-ca40-4d1a-a81f-ccec06313130 García-de-Yébenes-Castro, M. (Manuel)\|\|\|/items/1d967062-cbca-4f77-b0f0-fabea77e39db Gavira-Gómez, J.J. (Juan José)\|\|\|/items/a253ead5-4ef7-4b80-9aab-43b47605270e Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Iglesias-García, O. (Olalla)\|\|\|/items/93424e57-6115-4ea0-bcea-436fa10ec58d Mazo-Vega, M.M. (Manuel María)\|\|\|/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e Aranguren-López, X. (Xabier)\|\|\|/items/217519c3-f392-48cb-b4c9-87d4e2fd0570
author	Montero, P. (Pilar)\|\|\|/items/16d0acec-277d-4dba-9c72-cc02731289a5
author_facet	Montero, P. (Pilar)\|\|\|/items/16d0acec-277d-4dba-9c72-cc02731289a5 Flandes-Iparraguirre, M. (María)\|\|\|/items/a6e2b5bc-d2e2-4e55-a013-a472f9083dc1 Kuebler, B. (Brend)\|\|\|/items/093707f5-3c5b-48fa-b198-1896cd6206ab Arán, B. (Begoña)\|\|\|/items/cef67dd1-6904-42bb-b065-621b03516c2b Larequi-García, E. (Eduardo)\|\|\|/items/c82f1e42-2768-4025-bddc-ad659209577c Anaut, I. (Ilazki)\|\|\|/items/71e222fc-9392-4de1-889c-1fc0aa89b57c Coppiello, G. (Giulia)\|\|\|/items/d1d63554-537e-458e-8f86-02ae9264fe14 Veiga, A. (Anna)\|\|\|/items/f0b660bd-aaff-4fc0-9688-dc5e128d2ee9 Basurte-Elorz, M.T. (María Teresa)\|\|\|/items/ea05810c-ca40-4d1a-a81f-ccec06313130 García-de-Yébenes-Castro, M. (Manuel)\|\|\|/items/1d967062-cbca-4f77-b0f0-fabea77e39db Gavira-Gómez, J.J. (Juan José)\|\|\|/items/a253ead5-4ef7-4b80-9aab-43b47605270e Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Iglesias-García, O. (Olalla)\|\|\|/items/93424e57-6115-4ea0-bcea-436fa10ec58d Mazo-Vega, M.M. (Manuel María)\|\|\|/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e Aranguren-López, X. (Xabier)\|\|\|/items/217519c3-f392-48cb-b4c9-87d4e2fd0570
author_role	author
author2	Flandes-Iparraguirre, M. (María)\|\|\|/items/a6e2b5bc-d2e2-4e55-a013-a472f9083dc1 Kuebler, B. (Brend)\|\|\|/items/093707f5-3c5b-48fa-b198-1896cd6206ab Arán, B. (Begoña)\|\|\|/items/cef67dd1-6904-42bb-b065-621b03516c2b Larequi-García, E. (Eduardo)\|\|\|/items/c82f1e42-2768-4025-bddc-ad659209577c Anaut, I. (Ilazki)\|\|\|/items/71e222fc-9392-4de1-889c-1fc0aa89b57c Coppiello, G. (Giulia)\|\|\|/items/d1d63554-537e-458e-8f86-02ae9264fe14 Veiga, A. (Anna)\|\|\|/items/f0b660bd-aaff-4fc0-9688-dc5e128d2ee9 Basurte-Elorz, M.T. (María Teresa)\|\|\|/items/ea05810c-ca40-4d1a-a81f-ccec06313130 García-de-Yébenes-Castro, M. (Manuel)\|\|\|/items/1d967062-cbca-4f77-b0f0-fabea77e39db Gavira-Gómez, J.J. (Juan José)\|\|\|/items/a253ead5-4ef7-4b80-9aab-43b47605270e Prosper-Cardoso, F. (Felipe)\|\|\|/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1 Iglesias-García, O. (Olalla)\|\|\|/items/93424e57-6115-4ea0-bcea-436fa10ec58d Mazo-Vega, M.M. (Manuel María)\|\|\|/items/c871e8d9-ee5d-487b-97ef-7302feb8a02e Aranguren-López, X. (Xabier)\|\|\|/items/217519c3-f392-48cb-b4c9-87d4e2fd0570
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Transthyretin Amyloid cardiomyopathy Liver cells Pluripotent stem cell (iPSC)
topic	Transthyretin Amyloid cardiomyopathy Liver cells Pluripotent stem cell (iPSC)
description	Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells, which is then released systemically. Its amyloid deposition in the heart is linked to cardiac toxicity and progression toward heart failure. A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) from a patient suffering familial transthyretin amyloid cardiomyopathy carrying a c.128G>A (p.Ser43Asn) mutation in the TTR gene. This iPSC line offers a useful resource to study the disease pathophysiology and a cell-based model for therapeutic discovery.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023-09-27 2023 2023-01-01 2023 2023-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/67334
url	https://hdl.handle.net/10171/67334
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,301603

Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene

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