CMV and Immunosenescence: from basics to clinics

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “i...

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Bibliographic Details
Authors: Solana, Rafael, Tarazona, Raquel, Aiello, Allison E., Akbar, Arne N., Appay, Victor, Beswick, Mark, Bosch, Jos A., Campos, Carmen, Cantisán, Sara, Cicin Sain, Luca, Derhovanessian, Evelyna, Ferrando Martínez, Sara, Frasca, Daniela, Fulöp, Tamas, Govind, Sheila, Grubeck Loebenstein, Beatrix, Hill, Ann, Hurme, Mikko, Kern, Florian, Larbi, Anis, López-Botet, M. (Miguel), Maier, Andrea B., McElhaney, Janet E., Moss, Paul, Naumova, Elissaveta, Nikolich Zugich, Janko, Pera, Alejandra, Rector, Jerrarld L., Riddell, Natalie, Sanchez Correa, Beatriz, Sansoni, Paolo, Sauce, Delphine, Lier, Rene van, Wang, George C., Wills, Mark R., Zielinski, Maciej, Pawelec, Graham
Format: article
Status:Published version
Publication Date:2012
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/23187
Online Access:http://hdl.handle.net/10230/23187
http://dx.doi.org/10.1186/1742-4933-9-23
Access Level:Open access
Keyword:Immunitat cel·lular
Description
Summary:Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “immunosenescence”. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

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