CMV and Immunosenescence: from basics to clinics

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “i...

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Detalles Bibliográficos
Autores: Solana, Rafael, Tarazona, Raquel, Aiello, Allison E., Akbar, Arne N., Appay, Victor, Beswick, Mark, Bosch, Jos A., Campos, Carmen, Cantisán, Sara, Cicin Sain, Luca, Derhovanessian, Evelyna, Ferrando Martínez, Sara, Frasca, Daniela, Fulöp, Tamas, Govind, Sheila, Grubeck Loebenstein, Beatrix, Hill, Ann, Hurme, Mikko, Kern, Florian, Larbi, Anis, López-Botet, M. (Miguel), Maier, Andrea B., McElhaney, Janet E., Moss, Paul, Naumova, Elissaveta, Nikolich Zugich, Janko, Pera, Alejandra, Rector, Jerrarld L., Riddell, Natalie, Sanchez Correa, Beatriz, Sansoni, Paolo, Sauce, Delphine, Lier, Rene van, Wang, George C., Wills, Mark R., Zielinski, Maciej, Pawelec, Graham
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/23187
Acceso en línea:http://hdl.handle.net/10230/23187
http://dx.doi.org/10.1186/1742-4933-9-23
Access Level:acceso abierto
Palabra clave:Immunitat cel·lular
Descripción
Sumario:Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “immunosenescence”. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

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