Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
Peripheral nerve injury is a high-incidence clinical problem, significantly affecting the patient’s life quality and causing an enormous socioeconomic burden. It still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory. Accordingl...
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| Format: | doctoral thesis |
| Publication Date: | 2019 |
| Country: | España |
| Institution: | Universidad de Santiago de Compostela (USC) |
| Repository: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Language: | English |
| OAI Identifier: | oai:minerva.usc.gal:10347/18669 |
| Online Access: | http://hdl.handle.net/10347/18669 |
| Access Level: | Open access |
| Keyword: | Materias::Investigación::24 Ciencias de la vida::2490 Neurociencias::249001 Neurofisiología Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320502 Endocrinología |
| Summary: | Peripheral nerve injury is a high-incidence clinical problem, significantly affecting the patient’s life quality and causing an enormous socioeconomic burden. It still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory. Accordingly, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. In this scenario, the present study involves the obestatin/GPR39 system in the improvement of the peripheral nerve repair, by enhancing both neuroprotection and remyelination, and thus the regeneration of the damaged nerve, counteracting the severe loss of function and the atrophy of the innervated muscle. Consequently, obestatin is postulated as a potential therapeutic agent for peripheral nervous system regeneration. |
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