Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system

Peripheral nerve injury is a high-incidence clinical problem, significantly affecting the patient’s life quality and causing an enormous socioeconomic burden. It still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory. Accordingl...

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Detalles Bibliográficos
Autor: Sánchez Temprano, Agustín
Tipo de recurso: tesis doctoral
Fecha de publicación:2019
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/18669
Acceso en línea:http://hdl.handle.net/10347/18669
Access Level:acceso abierto
Palabra clave:Materias::Investigación::24 Ciencias de la vida::2490 Neurociencias::249001 Neurofisiología
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320502 Endocrinología
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spelling Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous systemSánchez Temprano, AgustínMaterias::Investigación::24 Ciencias de la vida::2490 Neurociencias::249001 NeurofisiologíaMaterias::Investigación::32 Ciencias médicas::3205 Medicina interna::320502 EndocrinologíaPeripheral nerve injury is a high-incidence clinical problem, significantly affecting the patient’s life quality and causing an enormous socioeconomic burden. It still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory. Accordingly, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. In this scenario, the present study involves the obestatin/GPR39 system in the improvement of the peripheral nerve repair, by enhancing both neuroprotection and remyelination, and thus the regeneration of the damaged nerve, counteracting the severe loss of function and the atrophy of the innervated muscle. Consequently, obestatin is postulated as a potential therapeutic agent for peripheral nervous system regeneration.Pazos Randulfe, YolandaPérez Camiña, JesúsRelova Quinteiro, José LuisUniversidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde20192019-01-0120192019-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/18669reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/186692026-06-15T12:47:27Z
dc.title.none.fl_str_mv Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
title Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
spellingShingle Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
Sánchez Temprano, Agustín
Materias::Investigación::24 Ciencias de la vida::2490 Neurociencias::249001 Neurofisiología
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320502 Endocrinología
title_short Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
title_full Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
title_fullStr Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
title_full_unstemmed Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
title_sort Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
dc.creator.none.fl_str_mv Sánchez Temprano, Agustín
author Sánchez Temprano, Agustín
author_facet Sánchez Temprano, Agustín
author_role author
dc.contributor.none.fl_str_mv Pazos Randulfe, Yolanda
Pérez Camiña, Jesús
Relova Quinteiro, José Luis
Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde
dc.subject.none.fl_str_mv Materias::Investigación::24 Ciencias de la vida::2490 Neurociencias::249001 Neurofisiología
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320502 Endocrinología
topic Materias::Investigación::24 Ciencias de la vida::2490 Neurociencias::249001 Neurofisiología
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320502 Endocrinología
description Peripheral nerve injury is a high-incidence clinical problem, significantly affecting the patient’s life quality and causing an enormous socioeconomic burden. It still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory. Accordingly, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. In this scenario, the present study involves the obestatin/GPR39 system in the improvement of the peripheral nerve repair, by enhancing both neuroprotection and remyelination, and thus the regeneration of the damaged nerve, counteracting the severe loss of function and the atrophy of the innervated muscle. Consequently, obestatin is postulated as a potential therapeutic agent for peripheral nervous system regeneration.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/18669
url http://hdl.handle.net/10347/18669
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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