Crosstalk between glucocorticoid receptor and obestatin/GPR39 system in skeletal muscle: an avenue for the treatment of muscular atrophy
Many pathological states characterized by muscle atrophy are associated with an increase in circulating glucocorticoids and poor patient prognosis. The development of treatments for glucocorticoid-induced wasting in skeletal muscle should be designed based on how the balance of muscle protein synthe...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/23179 |
| Acceso en línea: | http://hdl.handle.net/10347/23179 |
| Access Level: | acceso abierto |
| Palabra clave: | Materias::Investigación::24 Ciencias de la vida::2411 Fisiología humana::241110 Fisiología del músculo Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320502 Endocrinología |
| Sumario: | Many pathological states characterized by muscle atrophy are associated with an increase in circulating glucocorticoids and poor patient prognosis. The development of treatments for glucocorticoid-induced wasting in skeletal muscle should be designed based on how the balance of muscle protein synthesis and degradation is deregulated. Here, we investigated whether the obestatin/GPR39 system, an autocrine/paracrine signaling system acting on myogenesis and with anabolic effects on the skeletal muscle, could protect against glucocorticoid- induced muscle cell atrophy. |
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