Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados

Atherosclerosis is a leading cause of death and loss of productive life years worldwide. It is a complex and progressive disease due to the accumulation of lipids and fibrous elements in the large and medium size arteries, which causes endothelial dysfunction, oxidative stress and inflammation. The...

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Detalles Bibliográficos
Autor: Valero Muñoz, María
Tipo de recurso: tesis doctoral
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:español
OAI Identifier:oai:docta.ucm.es:20.500.14352/106008
Acceso en línea:https://hdl.handle.net/20.500.14352/106008
Access Level:acceso abierto
Palabra clave:616.13-002.2(043.2)
Arteriosclerosis
Cardiología
3205.01 Cardiología
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spelling Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicadosValero Muñoz, María616.13-002.2(043.2)ArteriosclerosisCardiología3205.01 CardiologíaAtherosclerosis is a leading cause of death and loss of productive life years worldwide. It is a complex and progressive disease due to the accumulation of lipids and fibrous elements in the large and medium size arteries, which causes endothelial dysfunction, oxidative stress and inflammation. The classic events of atherosclerosis have been greatly clarified by studies in animal models and culture cells. In brief, accumulation of lipoprotein particles in sites of lesion predilection on the arteries causes the attraction, adhesion and transmigration of monocytes across the endothelial monolayer into the intima mediated by molecules such as VCAM (vascular cell adhesion molecule) and MCP-1 (monocyte chemotactic protein-1). After that, monocytes proliferate and differentiate into macrophages and take up the lipoproteins, forming foam cells. Macrophages in the lesion have also a pro-inflammatory palette of functions, which produce high levels of cytokines such as tumour-necrosis factor-α (TNFα) or a number of interleukins. Atheroma formation also involves the recruitment of smooth muscle cells (SMCs) into the intima layer where they produce extracellular matrix molecules, including interstitial collagen and elastin, and form a fibrous cap that covers the plaque...Universidad Complutense de MadridHeras Jiménez, Natalia De LasRuiz-Roso Calvo De La Mora, BaltasarLahera Julia, VicenteUniversidad Complutense de Madrid20242024-07-1220242024-07-12doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/106008reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1060082026-06-02T12:44:21Z
dc.title.none.fl_str_mv Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
title Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
spellingShingle Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
Valero Muñoz, María
616.13-002.2(043.2)
Arteriosclerosis
Cardiología
3205.01 Cardiología
title_short Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
title_full Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
title_fullStr Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
title_full_unstemmed Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
title_sort Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
dc.creator.none.fl_str_mv Valero Muñoz, María
author Valero Muñoz, María
author_facet Valero Muñoz, María
author_role author
dc.contributor.none.fl_str_mv Heras Jiménez, Natalia De Las
Ruiz-Roso Calvo De La Mora, Baltasar
Lahera Julia, Vicente
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.13-002.2(043.2)
Arteriosclerosis
Cardiología
3205.01 Cardiología
topic 616.13-002.2(043.2)
Arteriosclerosis
Cardiología
3205.01 Cardiología
description Atherosclerosis is a leading cause of death and loss of productive life years worldwide. It is a complex and progressive disease due to the accumulation of lipids and fibrous elements in the large and medium size arteries, which causes endothelial dysfunction, oxidative stress and inflammation. The classic events of atherosclerosis have been greatly clarified by studies in animal models and culture cells. In brief, accumulation of lipoprotein particles in sites of lesion predilection on the arteries causes the attraction, adhesion and transmigration of monocytes across the endothelial monolayer into the intima mediated by molecules such as VCAM (vascular cell adhesion molecule) and MCP-1 (monocyte chemotactic protein-1). After that, monocytes proliferate and differentiate into macrophages and take up the lipoproteins, forming foam cells. Macrophages in the lesion have also a pro-inflammatory palette of functions, which produce high levels of cytokines such as tumour-necrosis factor-α (TNFα) or a number of interleukins. Atheroma formation also involves the recruitment of smooth muscle cells (SMCs) into the intima layer where they produce extracellular matrix molecules, including interstitial collagen and elastin, and form a fibrous cap that covers the plaque...
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-07-12
2024
2024-07-12
dc.type.none.fl_str_mv doctoral thesis
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dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/106008
url https://hdl.handle.net/20.500.14352/106008
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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