Efectos de un extracto de fibra de pulpa de algarroba rico en polifenoles sobre las alteraciones asociadas a la aterosclerosis experimental. Mecanismos implicados
Atherosclerosis is a leading cause of death and loss of productive life years worldwide. It is a complex and progressive disease due to the accumulation of lipids and fibrous elements in the large and medium size arteries, which causes endothelial dysfunction, oxidative stress and inflammation. The...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | español |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/106008 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/106008 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.13-002.2(043.2) Arteriosclerosis Cardiología 3205.01 Cardiología |
| Sumario: | Atherosclerosis is a leading cause of death and loss of productive life years worldwide. It is a complex and progressive disease due to the accumulation of lipids and fibrous elements in the large and medium size arteries, which causes endothelial dysfunction, oxidative stress and inflammation. The classic events of atherosclerosis have been greatly clarified by studies in animal models and culture cells. In brief, accumulation of lipoprotein particles in sites of lesion predilection on the arteries causes the attraction, adhesion and transmigration of monocytes across the endothelial monolayer into the intima mediated by molecules such as VCAM (vascular cell adhesion molecule) and MCP-1 (monocyte chemotactic protein-1). After that, monocytes proliferate and differentiate into macrophages and take up the lipoproteins, forming foam cells. Macrophages in the lesion have also a pro-inflammatory palette of functions, which produce high levels of cytokines such as tumour-necrosis factor-α (TNFα) or a number of interleukins. Atheroma formation also involves the recruitment of smooth muscle cells (SMCs) into the intima layer where they produce extracellular matrix molecules, including interstitial collagen and elastin, and form a fibrous cap that covers the plaque... |
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