Mice with Pulmonary Tuberculosis Treated with Mycobacterium vaccae Develop Strikingly Enhanced Recall Gamma Interferon Responses to M. vaccae Cell Wall Skeleton

Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma in...

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Bibliographic Details
Authors: Rodríguez Güell, Elisabeth, Agustí, Gemma, Corominas Sánchez, Mercè, Cardona, Pere-Joan, Luquin, Marina, Julián, Esther
Format: article
Status:Published version
Publication Date:2008
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126418
Online Access:https://hdl.handle.net/2445/126418
Access Level:Open access
Keyword:Mycobacterium tuberculosis
Ratolins (Animals de laboratori)
Mice (Laboratory animals)
Description
Summary:Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.

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