Mice with Pulmonary Tuberculosis Treated with Mycobacterium vaccae Develop Strikingly Enhanced Recall Gamma Interferon Responses to M. vaccae Cell Wall Skeleton

Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma in...

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Detalles Bibliográficos
Autores: Rodríguez Güell, Elisabeth, Agustí, Gemma, Corominas Sánchez, Mercè, Cardona, Pere-Joan, Luquin, Marina, Julián, Esther
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126418
Acceso en línea:https://hdl.handle.net/2445/126418
Access Level:acceso abierto
Palabra clave:Mycobacterium tuberculosis
Ratolins (Animals de laboratori)
Mice (Laboratory animals)
Descripción
Sumario:Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.

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