Mice with Pulmonary Tuberculosis Treated with Mycobacterium vaccae Develop Strikingly Enhanced Recall Gamma Interferon Responses to M. vaccae Cell Wall Skeleton

Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma in...

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Detalhes bibliográficos
Autores: Rodríguez Güell, Elisabeth, Agustí, Gemma, Corominas Sánchez, Mercè, Cardona, Pere-Joan, Luquin, Marina, Julián, Esther
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2008
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126418
Acesso em linha:https://hdl.handle.net/2445/126418
Access Level:Acceso aberto
Palavra-chave:Mycobacterium tuberculosis
Ratolins (Animals de laboratori)
Mice (Laboratory animals)
Descrição
Resumo:Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.

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