Increased Natural Killer Cells Are Associated with Alcohol Liver Fibrosis and with T Cell and Cytotoxic Subpopulations Change

Natural killer (NK) cells play a therapeutic role in liver fibrosis (LF). We aimed to analyze NK cells in heavy drinkers without cirrhosis or decompensated liver disease and establish correlations with other related subpopulations. Data on sociodemographic characteristics, alcohol consumption, labor...

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Bibliographic Details
Authors: Zuluaga Blanco, Yenny Paola|||0000-0002-0247-0351, Teniente Serra, Aina|||0000-0003-3440-804X, Fuster, Daniel|||0000-0003-1262-5860, Quirant, Bibiana|||0000-0002-3875-8074, Hernandez Rubio, Anna|||0000-0001-8612-7827, Martínez Cáceres, Eva María|||0000-0002-6762-8025, Muga, Roberto|||0000-0001-6301-431X
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:252214
Online Access:https://ddd.uab.cat/record/252214
https://dx.doi.org/urn:doi:10.3390/jcm11020305
Access Level:Open access
Keyword:Alcohol liver disease
FIB-4 score
Lymphocyte population
Description
Summary:Natural killer (NK) cells play a therapeutic role in liver fibrosis (LF). We aimed to analyze NK cells in heavy drinkers without cirrhosis or decompensated liver disease and establish correlations with other related subpopulations. Data on sociodemographic characteristics, alcohol consumption, laboratory parameters, and immunophenotyping of NK (CD16 + /CD56 +), T (CD3 +), B (CD19 +), NKT (CD16 + /CD56 + /CD3 +), and cytotoxic (CD3 - CD8 +) cells were collected. Fibrosis-4 (FIB-4) scores were used to compare patients without (FIB-4 < 1.45) and with (FIB-4.

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