Increased Natural Killer Cells Are Associated with Alcohol Liver Fibrosis and with T Cell and Cytotoxic Subpopulations Change

Natural killer (NK) cells play a therapeutic role in liver fibrosis (LF). We aimed to analyze NK cells in heavy drinkers without cirrhosis or decompensated liver disease and establish correlations with other related subpopulations. Data on sociodemographic characteristics, alcohol consumption, labor...

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Detalles Bibliográficos
Autores: Zuluaga Blanco, Yenny Paola|||0000-0002-0247-0351, Teniente Serra, Aina|||0000-0003-3440-804X, Fuster, Daniel|||0000-0003-1262-5860, Quirant, Bibiana|||0000-0002-3875-8074, Hernandez Rubio, Anna|||0000-0001-8612-7827, Martínez Cáceres, Eva María|||0000-0002-6762-8025, Muga, Roberto|||0000-0001-6301-431X
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:252214
Acceso en línea:https://ddd.uab.cat/record/252214
https://dx.doi.org/urn:doi:10.3390/jcm11020305
Access Level:acceso abierto
Palabra clave:Alcohol liver disease
FIB-4 score
Lymphocyte population
Descripción
Sumario:Natural killer (NK) cells play a therapeutic role in liver fibrosis (LF). We aimed to analyze NK cells in heavy drinkers without cirrhosis or decompensated liver disease and establish correlations with other related subpopulations. Data on sociodemographic characteristics, alcohol consumption, laboratory parameters, and immunophenotyping of NK (CD16 + /CD56 +), T (CD3 +), B (CD19 +), NKT (CD16 + /CD56 + /CD3 +), and cytotoxic (CD3 - CD8 +) cells were collected. Fibrosis-4 (FIB-4) scores were used to compare patients without (FIB-4 < 1.45) and with (FIB-4.

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